Henry T Brush

US Patent:

20070123449, May 31, 2007

Filed:

Oct 31, 2006

Appl. No.:

11/590562

Inventors:

Henry Brush - Arlington MA, US
Michael Lipp - Framingham MA, US
Jennifer Schmitke - Boston MA, US

Assignee:

Advanced Inhalation Research, Inc. - Cambridge MA

International Classification:

A61K 38/28
A61K 31/19

US Classification:

514003000, 514574000

Abstract:

The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.

US Patent:

56113447, Mar 18, 1997

Filed:

Mar 5, 1996

Appl. No.:

8/611248

Inventors:

Howard Bernstein - Cambridge MA
Julie A. Straub - Winchester MA
Henry T. Brush - Somerville MA
Richard E. Wing - Cambridge MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 800

US Classification:

12866202

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

US Patent:

61326992, Oct 17, 2000

Filed:

Sep 22, 1998

Appl. No.:

9/158295

Inventors:

Howard Bernstein - Cambridge MA
Julie Ann Straub - Winchester MA
Henry T. Brush - Somerville MA
Richard E. Wing - Cambridge MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 813

US Classification:

424 952

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

US Patent:

58536981, Dec 29, 1998

Filed:

Nov 8, 1996

Appl. No.:

8/745676

Inventors:

Julie Ann Straub - Winchester MA
Edith Mathiowitz - Brookline MA
Howard Bernstein - Cambridge MA
Henry T. Brush - Somerville MA
Richard E. Wing - Bloomfield NJ

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61B 813

US Classification:

424 952

Abstract:

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein. The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.

US Patent:

60457775, Apr 4, 2000

Filed:

Jun 30, 1997

Appl. No.:

8/885933

Inventors:

Charles C. Church - Arlington MA
Howard Bernstein - Cambridge MA
Julie Ann Straub - Winchester MA
Henry T. Brush - Somerville MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61K 4904
A61B 814

US Classification:

424 952

Abstract:

It has been discovered microparticles formed from natural or synthetic polymer with thicker walls have significantly enhanced echogenicity as compared with microparticles having thinner walls. The effect of wall thickness has been determined experimentally as well as inserted into a formula for use in predicting the optimum conditions. In the preferred embodiment, the polymers are synthetic biodegradable polymers and the wall thickness is between about 100 and 660 nm, although wall thicknesses from about 20 nm to in excess of 500 nm can be used. The microparticles are manufactured with a diameter suitable for the targeted tissue to be imaged, for example, with a diameter of between 0. 5 and 8 microns for intravascular administration, and a diameter of between 0. 5 and 5 mm for oral administration for imaging of the gastrointestinal tract or other lumens.

US Patent:

58372210, Nov 17, 1998

Filed:

Jul 29, 1996

Appl. No.:

8/681710

Inventors:

Howard Bernstein - Cambridge MA
Julie Ann Straub - Winchester MA
Henry T. Brush - Somerville MA
Charles C. Church - Arlington MA

Assignee:

Acusphere, Inc. - Cambridge MA

International Classification:

A61K 4904
A61K 914

US Classification:

424 952

Abstract:

It has been discovered that the incorporation of gases, especially fluorinated gases such as perfluorocarbons, into microparticles formed from the combination of a natural or synthetic polymer and lipid have significantly enhanced echogenicity as compared with microparticles not including the lipid. Compounds other than lipids which are hydrophobic and limit the penetration and/or uptake of water into the microparticles can also be incorporated into the microparticles to enhance echogenicity. In the preferred embodiment, the polymers are synthetic biodegradable polymers. The microparticles are manufactured with a diameter suitable for the targeted tissue to be imaged, for example, with a diameter of between 0. 5 and 8 microns for intravascular administration, and a diameter of between 0. 5 and 5 mm for oral administration for imaging of the gastrointestinal tract or other lumens.