Hua Lau Wan

US Patent:

20110135706, Jun 9, 2011

Filed:

Nov 30, 2010

Appl. No.:

12/956058

Inventors:

Hui Xu - Plainsboro NJ, US
Wendell Sun - Warrington PA, US
Cunqi Cui - East Windsor NJ, US
Hua Wan - Princeton NJ, US

International Classification:

A61K 35/44
A61K 9/10
A61K 38/39
A61P 25/02

US Classification:

424423, 424484, 424569, 424 931, 514 182

Abstract:

Devices and methods for treating defects in peripheral nerves are provided. The devices can include acellular arterial tissue matrices that facilitate regrowth of nerve tissue across a gap or defect in a peripheral nerve.

US Patent:

20130028984, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560362

Inventors:

Hui Xu - Plainsboro NJ, US
Wenquan Sun - Warrington PA, US
Hua Wan - Princeton NJ, US
Rick Owens - Stewartsville NJ, US

International Classification:

A61K 38/17
A61P 31/04
A61K 33/38
A61P 29/00
A61K 38/18

US Classification:

424618, 514 209, 514 76, 514 91, 514 81, 514 82

Abstract:

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

US Patent:

20200383771, Dec 10, 2020

Filed:

Jul 27, 2020

Appl. No.:

16/939414

Inventors:

- Madison NJ, US
Hua Wan - Princeton NJ, US
I-Chien Liao - Princeton NJ, US

International Classification:

A61F 2/08
A61L 27/36
A61K 35/34

Abstract:

Disclosed herein are muscle implants and methods of making muscle implants comprising one or more decellularized muscle matrices. The muscle matrices can, optionally, be joined to one or more decellularized dermal matrices. The muscle implants can be used to enhance muscle volume or to treat muscle damage, defects, and/or disorders. The decellularized muscle matrices in the implants retain at least some of the myofibers found in a muscle tissue prior to processing.

US Patent:

20190231931, Aug 1, 2019

Filed:

Apr 9, 2019

Appl. No.:

16/379276

Inventors:

- Madison NJ, US
Li Ting Huang - Branchburg NJ, US
Hua Wan - Princeton NJ, US
Rick T. Owens - Stewartsville NJ, US
Nathaniel Bachrach - Clifton NJ, US

International Classification:

A61L 27/36
G01N 33/573
A61L 27/54
A61L 27/24
A61L 27/58

Abstract:

Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.

US Patent:

20190015457, Jan 17, 2019

Filed:

Sep 17, 2018

Appl. No.:

16/133306

Inventors:

- Madison NJ, US
Hui Xu - Plainsboro NJ, US
Hua Wan - Princeton NJ, US

International Classification:

A61K 35/44
A61L 26/00
A61L 27/36
A61L 27/52
A61L 27/54

Abstract:

A tissue-derived hydrogel, as well as methods of making and using such hydrogels, are provided.

US Patent:

20180216062, Aug 2, 2018

Filed:

Mar 26, 2018

Appl. No.:

15/935740

Inventors:

- Branchburg NJ, US
Hui Xu - Plainsboro NJ, US
Li Ting Huang - Branchburg NJ, US
Wenquan Sun - Warrington PA, US
Hua Wan - Princeton NJ, US

International Classification:

C12N 5/00
A61L 27/56
A61L 27/36

Abstract:

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.

US Patent:

20170348460, Dec 7, 2017

Filed:

May 26, 2017

Appl. No.:

15/606924

Inventors:

- Branchburg NJ, US
Hua Wan - Princeton NJ, US
Hui Xu - Plainsboro NJ, US
Dennis Y. Lee - Scotch Plains NJ, US

International Classification:

A61L 27/36
A61L 27/54
A61L 31/16
A61K 35/35
A61K 38/39

Abstract:

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a fluid containing at least one agent to produce a tissue matrix with variable mechanical and/or biological properties

US Patent:

20160090572, Mar 31, 2016

Filed:

Dec 8, 2015

Appl. No.:

14/962125

Inventors:

- Branchburg NJ, US
Hui Xu - Plainsboro NJ, US
Li Ting Huang - Branchburg NJ, US
Wenquan Sun - Warrington PA, US
Hua Wan - Princeton NJ, US

International Classification:

C12N 5/00

Abstract:

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.