Itzhak D Goldberg

US Patent:

6432406, Aug 13, 2002

Filed:

Jul 26, 2000

Appl. No.:

09/625820

Inventors:

Itzhak D. Goldberg - Englewood NJ
Eliot M. Rosen - Port Washington NY

Assignee:

North Shore - Long Island Jewish Research Institute - Manhasset NY

International Classification:

A61K 3800

US Classification:

4241581, 4241301, 512 2, 512 8, 530300, 530350, 5303871, 530399

Abstract:

This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.

US Patent:

6498144, Dec 24, 2002

Filed:

Jun 23, 2000

Appl. No.:

09/602302

Inventors:

Itzhak D. Goldberg - Englewood NJ
Eliot M. Rosen - Port Washington NY

Assignee:

North Shore - Long Island Jewish Research Institute - Manhasset NY

International Classification:

A61K 3800

US Classification:

514 12, 514 2, 530324, 530350, 530399

Abstract:

This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.

US Patent:

6589997, Jul 8, 2003

Filed:

Jun 29, 2001

Appl. No.:

09/896832

Inventors:

Sivaram Pillarisetti - Norcross GA
Itzhak D. Goldberg - Englewood NJ

Assignee:

North Shore-Long Island Jewish Health System - New Hyde Park NY

International Classification:

A01N 3500

US Classification:

514685, 514277, 514461, 514438

Abstract:

The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

US Patent:

6610726, Aug 26, 2003

Filed:

Dec 19, 2001

Appl. No.:

10/026672

Inventors:

Sivaram Pillarisetti - Norcross GA
Itzhak D. Goldberg - Englewood NJ

Assignee:

North Shore-Long Island Jewish Research Institute - Manhasset NY

International Classification:

A61K 31415

US Classification:

514406, 514407, 5483657, 5483641, 5483741, 5483731, 5483761

Abstract:

The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction.

US Patent:

6855728, Feb 15, 2005

Filed:

Jun 6, 2003

Appl. No.:

10/456326

Inventors:

Sivaram Pillarisetti - Norcross GA, US
Itzhak D. Goldberg - Englewood NJ, US

Assignee:

North Shore-Long Island Jewish Health System - New Hyde Park NY

International Classification:

A61K031/415

US Classification:

514406

Abstract:

The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

US Patent:

20050096372, May 5, 2005

Filed:

Dec 8, 2004

Appl. No.:

11/007333

Inventors:

Sivaram Pillarisetti - Norcross GA, US
Itzhak Goldberg - Englewood NJ, US

International Classification:

A61K031/415

US Classification:

514406000

Abstract:

The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

US Patent:

20110237633, Sep 29, 2011

Filed:

Dec 11, 2009

Appl. No.:

13/133972

Inventors:

Bijoy Panicker - Holbrook NY, US
Lambertus J.W.M. Oehlen - Westbury NY, US
Itzhak G. Goldberg - Englewood NJ, US

International Classification:

A61K 31/42
C07D 233/56
C07D 261/06
C07D 257/04
C07D 207/323
A61K 31/4164
A61K 31/41
A61K 31/40
A61P 11/00
A61P 31/14
A61P 9/10
A61P 37/02
A61P 1/16
A61P 9/12
A61P 3/10
A61P 25/00
A61P 13/12

US Classification:

514378, 5483461, 548240, 548250, 548564, 514396, 514381, 514427

Abstract:

The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role.

US Patent:

20120190668, Jul 26, 2012

Filed:

Aug 12, 2010

Appl. No.:

13/384760

Inventors:

Lambertus J.W.M. Oehlen - Westbury NY, US
Itzhak D. Goldberg - Englewood NJ, US

International Classification:

A61K 31/55
A61K 31/4155
A61K 31/415
A61K 31/5377
A61K 31/4439
A61P 43/00
A61K 31/502
A61K 31/541
C12N 5/077
C12N 5/0793
C12N 5/078
C12N 5/071
A61K 31/454

US Classification:

51421705, 435375, 514406, 5142365, 514341, 514326, 514248, 5142282

Abstract:

The present invention provides methods for enhancing cellular transplantation by exposing cells in vitro or ex vivo, or a recipient of cells, to a small molecule hepatocyte growth factor/scatter factor mimetic. Exemplary compounds are described.

Author:

Itzhak Goldberg

ISBN #:

0821327259

Author:

Itzhak Goldberg

ISBN #:

0821336584

Author:

Itzhak Goldberg

ISBN #:

2738465692

Author:

Itzhak Goldberg

ISBN #:

2842300262

Author:

Itzhak Goldberg

ISBN #:

3901935088