William A. Carroll - Evanston IL Yiyuan Chen - Waukegan IL Irene Drizin - Wadsworth IL James F. Kerwin - Grayslake IL Jimmie L. Moore - Gurnee IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 314353
US Classification:
514290, 546 79
Abstract:
Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
4-Imidazole Derivatives Of Benzyl And Restricted Benzyl Sulfonamides, Sulfamides, Ureas, Carbamates, And Amides And Their Use
Robert Altenbach - Chicago IL, US Michael Meyer - Lake Villa IL, US James Kerwin - Grayslake IL, US Albert Khilevich - Buffalo Grove IL, US Teodozyj Kolasa - Lake Villa IL, US Jeffrey Rohde - Evanston IL, US William Carroll - Evanston IL, US Xenia Searle - Grayslake IL, US Fan Yang - Highwood IL, US
International Classification:
C07D233/54 C07D233/84
US Classification:
548/320100, 548/326500
Abstract:
Compounds of formula I are useful in treating diseases prevented by or ameliorated with agonists. Also disclosed are agonist compositions and a method of activating adrenoceptors in a mammal.
James F. Kerwin - Mundelein IL Mark W. Holladay - Libertyville IL Michael J. Bennett - Morton Grove IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 3147 C07D21522 C07D20918
US Classification:
514312
Abstract:
Analogs of CCK-tetrapeptides, which analogs have the formula ##STR1## wherein A, B, D, R. sup. 1, R. sup. 2, R. sup. 3, and R. sup. 4 are specifically defined, having activity as CCK antagonists, useful in the treatment or prevention of disorders of the gastrointestinal, central nervous, appetite regulating or pain regulating systems.
Benzopyranopyrrole And Benzopyranopyridine .Alpha.-1 Adrenergic Compounds
Michael D. Meyer - Lake Villa IL Robert J. Altenbach - Chicago IL Fatima Z. Basha - Lake Forest IL William A. Carroll - Evanston IL Irene Drizin - Wadsworth IL James F. Kerwin - Grayslake IL Michael D. Wendt - North Chicago IL Anthony R. Haight - Wadsworth IL Weijiang Zhang - Grayslake IL
International Classification:
A61K 31505 C07D23900 C07D47100 C07D48700
US Classification:
514259
Abstract:
The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are. alpha. -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are. alpha. -1 antagonist compositions and a method for antagonizing. alpha. -1 adrenoreceptors and treating BPH.
Derivatives Of D-Glutamic Acid And D-Aspartic Acid
Alex M. Nadzan - Libertyville IL James F. Kerwin - Mundelein IL Chun W. Lin - Wood Dale IL
International Classification:
C07D21522 A61K 3147
US Classification:
514312
Abstract:
A compound of the formula: ##STR1## wherein R. sub. 1 and R. sub. 2 are substituents; R. sub. 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O). sub. 2 ; Ar is a heterocyclic group; and n is 1 to 3. Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.
Benzopyranopyrrole And Benzopyranopyridine .Alpha.-1 Adenergic Compounds
Michael D. Meyer - Lake Villa IL Robert J. Altenbach - Chicago IL Fatima Z. Basha - Lake Forest IL William A. Carroll - Evanston IL Irene Drizin - Wadsworth IL James F. Kerwin - Grayslake IL Michael D. Wendt - North Chicago IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 31505 C07D23900 C07D47100 C07D48700
US Classification:
514267
Abstract:
The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are. alpha. -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are. alpha. -1 antagonist compositions and a method for antagonizing. alpha. -1 adrenoreceptors and tr.
Guanidino Compounds As Regulators Of Nitric Oxide Synthase
Marlon Daniel Cowart - Round Lake Beach IL Donald N. Halbert - Libertyville IL James F. Kerwin - Grayslake IL Teresa McNally - Gurnee IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C12N 1500 C12N 1585 C12N 1563 C12N 912
US Classification:
435194
Abstract:
The present invention provides an adenosine kinase protein having an identified structural formula. The identified protein or similar adenosine kinase proteins having residues as claimed and recited herein may be isolated and purified from natural sources or produced by recombinant DNA technology.
Isbn (Books And Publications)
Combinatorial Chemistry And Molecular Diversity In Drug Discovery
Craig Anderson, J C, Paul Smith, Joseph Dorneo, Keith Anderson, Erik Lange, David Fernandez, Lou Stellato, George Lee, Robert Wondolowski, James Nichols, Bob Scheurer