James G Schleck

US Patent:

6455727, Sep 24, 2002

Filed:

Dec 14, 2001

Appl. No.:

10/017136

Inventors:

Vilas M. Chopdekar - Edison NJ
James R. Schleck - Somerset NJ
Hemant S. Desai - Flemington NJ

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

C07C 6988

US Classification:

560102, 514530, 514464, 514653, 514357, 560 68

Abstract:

The invention pertains to a process for preparing carbetapentane tannate. The process involves the steps of heating carbetapentane to a temperature of about 80 to about 120Â C. and slowly adding tannic acid to the carbetapentane while agitating the reaction mixture. Preferably, no water or any other solvent or diluent is utilized in the process.

US Patent:

6472380, Oct 29, 2002

Filed:

Nov 8, 2000

Appl. No.:

09/708197

Inventors:

James R. Schleck - Somerset NJ
Christopher M. Burger - Highstown NJ
Vilas M. Chopdekar - Edison NJ

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

A61K 3170

US Classification:

514 62, 536 172, 536 187, 536 552, 536 553

Abstract:

Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i. e. , the cation is potassium, sodium, magnesium, lithium, calcium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with a hydroxide of the metal in the presence of water to form a first aqueous solution of the free glucosamine base and a chloride of the metal, acidifying the first aqueous solution with sulfuric acid to form a second aqueous solution of glucosamine sulfate and the chloride of the metal, and thereafter freeze-drying the second aqueous solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.

US Patent:

6670370, Dec 30, 2003

Filed:

Oct 28, 2002

Appl. No.:

10/281725

Inventors:

Vilas M. Chopdekar - Edison NJ
James R. Schleck - Somerset NJ
Hemant S. Desai - Flemington NJ

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

A61K 31485

US Classification:

514289, 514850, 514855, 514326, 560 68, 546 74

Abstract:

The invention pertains to a composition comprising dextromethorphan tannate and to a method for preparing dextromethorphan tannate by reacting dextromethorphan at a temperature of about 80 to about 180Â C. with tannic acid either neat or as an aqueous slurry containing about 5 to about 30 wt. % water. The dextromethorphan tannate has extended release properties and is useful in pharmaceutical compositions as an antitussive for human beings.

US Patent:

6677381, Jan 13, 2004

Filed:

Dec 14, 2001

Appl. No.:

10/017131

Inventors:

James R. Schleck - Somerset NJ
Vilas M. Chopdekar - Edison NJ

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

A61K 31135

US Classification:

514653, 514646, 514849, 560 68

Abstract:

The invention pertains to a novel composition comprising guaifenesin tannate and to a method for preparing guaifenesin tannate by reacting guaifenesin with tannic acid at a temperature above the melting point of guaifenesin. The guaifenesin tannate has extended release properties and is useful in pharmaceutical compositions as an expectorant in warm-blooded animals or as a muscle relaxant in non-human animals.

US Patent:

6833360, Dec 21, 2004

Filed:

Dec 20, 2002

Appl. No.:

10/326361

Inventors:

Sham N. Redkar - Bound Brook NJ
James R. Schleck - Somerset NJ
Vilas M. Chopdekar - Edison NJ

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

A61K 317024

US Classification:

514 23, 536119, 560 68

Abstract:

The invention pertains to a method for preparing pseudoephedrine tannate by reacting pseudoephedrine free base at a temperature of about 70 to about 110Â C. with tannic acid neat or as an aqueous slurry containing about 5 to about 30 wt. % water.

US Patent:

7001886, Feb 21, 2006

Filed:

Apr 16, 2004

Appl. No.:

10/826538

Inventors:

Sham N. Redkar - Bound Brook NJ, US
Raja G. Achari - Millington NJ, US
James R. Schleck - Somerset NJ, US
Vilas M. Chopdekar - Edison NJ, US

Assignee:

Jame Fine Chemicals, Inc. - Bound Brook NJ

International Classification:

A61K 38/00
C07H 13/02

US Classification:

514 13, 536119

Abstract:

The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150 C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.

US Patent:

7388001, Jun 17, 2008

Filed:

Sep 9, 2005

Appl. No.:

11/223687

Inventors:

Vilas M. Chopdekar - Edison NJ, US
Michelle Y. McGough - Lebanon IN, US
Hemant S. Desai - Piscataway NJ, US
James G. Schleck - Metuchen NJ, US
Sham N. Redkar - Bound Brook NJ, US

Assignee:

JFC Technolries, LLC - Bound Brook NJ

International Classification:

A61K 31/70
C07H 5/04

US Classification:

514 62, 536 552, 536 553

Abstract:

Glucosamine sulfate having a purity of at least about 99 wt. %, and a maximum halide content of about 0. 01 wt. %. Preferably, the glucosamine sulfate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; polypropylene glycol homopolymers and copolymers; ethylcellulose; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated glucosamine sulfate composition will be stable at ambient temperatures and upon exposure to the atmosphere.

US Patent:

52943771, Mar 15, 1994

Filed:

Jan 27, 1993

Appl. No.:

8/009892

Inventors:

Vilas M. Chopdekar - Edison NJ
James R. Schleck - Somerset NJ

International Classification:

C09K 300

US Classification:

252700

Abstract:

A process for the restoration of the initial chemical lighting potential of the oxalate component of a chemiluminescent lighting system. The oxalate component comprises an oxalate diester in a first liquid solution which prior to restoration exhibits a failure to produce initial high intensity luminosity upon mixture of the oxalate component with a liquid activator component comprising a peroxide in a second liquid solution. The process comprises contacting the oxalate component with magnesium silicate or calcium silicate for a period of time sufficient to correct the failure and thereafter separating the oxalate component from the selected silicate.