Pfizer
Associate Research Fellow
Pfizer
Senior Principal Scientist
Pfizer Global Research & Development Ann Arbor Sep 2001 - Jun 2007
Senior Principal Scientist
Molecular Geriatrics Sep 2000 - Jul 2001
Scientist
Argonne National Laboratory Jul 1998 - Jun 1999
Special Term Appointee
Education:
Northwestern University 1986 - 1990
Doctorates, Doctor of Philosophy
University of Chicago 1981 - 1986
Bachelors, Bachelor of Arts, Biology
Skills:
Drug Discovery Protein Chemistry Protein Purification Assay Development Biotechnology Vaccines Drug Development Structural Biology Life Sciences Pharmaceutical Industry Crystallization Cell Clinical Trials Laboratory Hplc Process Simulation Regulatory Submissions
Alan Daniel BROWN - Deal, GB Heather Lynn DAVIS - Dunrobin, CA David P. GERVAIS - Gomeldon, GB Lyn Howard JONES - Canterbury, GB James R. MERSON - Rancho Santa Fe CA, US David Cameron PRYDE - Walmer, GB David R. STEAD - San Diego CA, US Michael J. MCCLUSKIE - Ottawa, CA Jennifer Marie THORN - Chesterfield MO, US Paul Robert MEHELIC - St. Charles MO, US Parag Ashok KOLHE - Wildwood MO, US Keshab BHATTACHARYA - Brentwood MO, US Jari Ilmari FINNEMAN - Glencoe MO, US Erin Kristen PARSONS - University City MO, US Nickolas ANASTASIOU - Chesterfield MO, US
The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III):wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.
Syed Saleem Ahmed - Chesterfield MO, US Lavinia Marina Lewis - Chesterfield MO, US Brandi Rae Osborne - Chesterfield MO, US Sandipan Sinha - Manchester MO, US Jennifer Marie Thorn - Chesterfield MO, US Ferhana Zaman - Chesterfield MO, US
The present disclosure relates to vaccine compositions, particularly KLH-peptide conjugates, and methods of making such compositions. The present disclosure further relates to methods of reducing abnormal cell growth using the composistions described herein.
Matrix Metalloproteinase Inhibitors And Methods For Identification Of Lead Compounds
Anne-Claude Dublanchet - Fresnes Cedex, FR Charles Andrianjara - Fresnes Cedex, FR Roger Wrigglesworth - Fresnes Cedex, FR Claude Bertrand - Fresnes Cedex, FR Pierre Ducrot - Fresnes Cedex, FR Renaud Morales - Fresnes Cedex, FR Venkataraman Thanabal - Ann Arbor MI, US Alexander Pavlovsky - Ann Arbor MI, US Margaret O'Gara - Fresnes Cedex, FR Jennifer Thorn - Ann Arbor MI, US Delphine Compere - Fresnes Cedex, FR
International Classification:
A61K038/17
US Classification:
514/012000
Abstract:
The invention relates to compounds that are selective inhibitors of matrix metalloproteinases, to pharmaceutical compositions containing them and to their use in the prevention and/or treatment of MMP-associated diseases. The invention also relates to methods for identification of lead compounds that are selective inhibitors of matrix metalloproteinases. The compounds have the properties that they: (a) bind allosterically to a matrix metalloproteinase or small group of metallic metalloproteinases; (b) bind into at least the S1′ pocket, at least the S1″ pocket (as defined) or at least the S1′ pocket and the S1″ pocket of said matrix metalloproteinase; and (c) exhibit selectivity for a matrix metalloproteinase or group of matrix metalloproteinases other than MMP-13.
- Hampton NJ, US Lavinia Marina LEWIS - Chesterfield MO, US Brandi Rae OSBORNE - Chesterfield MO, US Sandipan SINHA - Manchester MO, US Jennifer Marie THORN - Chesterfield MO, US Ferhana ZAMAN - Chesterfield MO, US
International Classification:
A61K 39/385
Abstract:
The present disclosure relates to vaccine compositions, particularly KLH-peptide conjugates, and methods of making such compositions. The present disclosure further relates to methods of reducing abnormal cell growth using the compositions described herein.
Conjugates For The Prevention Or Treatment Of Nicotine Addiction
- New York NY, US Heather Lynn Davis - Ottawa, CA David P. Gervais - Gomeldon, GB Lyn Howard Jones - Canterbury, GB James R. Merson - Rancho Santa Fe CA, US David Cameron Pryde - Walmer, GB David R. Stead - San Diego CA, US Michael J. McCluskie - Ottawa, CA Jennifer Marie Thorn - Chesterfield MO, US Paul Robert Mehelic - St. Charles MO, US Parag Ashok Kolhe - Wildwood MO, US Keshab Bhattacharya - Brentwood MO, US Jari Ilmari Finneman - Glencoe MO, US Erin Kristen Parsons - University City MO, US Nickolas Anastasiou - Chesterfield MO, US
International Classification:
A61K 39/385 A61K 39/39 C07K 14/34 C07D 401/04
Abstract:
The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III):wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.
- PHILLIPSBURG NJ, US Lavinia Marina LEWIS - Chesterfield MO, US Brandi Rae OSBORNE - Chesterfield MO, US Sandipan SINHA - Manchester MO, US Jennifer Marie THORN - Chesterfield MO, US Ferhana ZAMAN - Chesterfield MO, US
International Classification:
A61K 39/385
US Classification:
530395
Abstract:
The present disclosure relates to vaccine compositions, particularly KLH-peptide conjugates, and methods of making such compositions. The present disclosure further relates to methods of reducing abnormal cell growth using the compositions described herein.
Jennifer Thorn 1990 graduate of Brewster High School in Brewster, NY is on Memory Lane. Get caught up with Jennifer and other high school alumni from Brewster