Joel Voldman

US Patent:

7425253, Sep 16, 2008

Filed:

Jan 31, 2005

Appl. No.:

11/045487

Inventors:

Joel Voldman - Somerville MA, US
Brian Michael Taff - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01N 27/447
G01N 27/453

US Classification:

204547, 204643

Abstract:

The present invention provides a device and methods of use thereof in microscale cell sorting. This invention provides sorting cytometers, which trap individual cells within vessels following exposure to dielectrophoresis, allow for the assaying of trapped cells, such that a population is identified whose isolation is desired, and their isolation.

US Patent:

8021877, Sep 20, 2011

Filed:

Apr 10, 2006

Appl. No.:

11/400801

Inventors:

Adam Rosenthal - Cambridge MA, US
Joel Voldman - Somerville MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12N 5/00

US Classification:

435325

Abstract:

This invention provides devices comprising substrates with wells for the patterning of particles or cells. Such devices are loaded with a suspension of particles or cell, and the entrapped particles or cells are transferred to a second substrate, where patterning of individual particles or cells occurs. Methods of cellular analysis, cell growth studies, surface modification, optical display fabrication and curved surface patterning using devices of this invention are described.

US Patent:

8454813, Jun 4, 2013

Filed:

Apr 24, 2008

Appl. No.:

12/081995

Inventors:

Joel Voldman - Somerville MA, US
Brian Michael Taff - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

G01N 27/453

US Classification:

204643

Abstract:

The present invention provides a device and methods of use thereof in microscale cell sorting. This invention provides sorting cytometers, which trap individual cells within vessels following exposure to dielectrophoresis, allow for the assaying of trapped cells, such that a population is identified whose isolation is desired, and their isolation.

US Patent:

20040166555, Aug 26, 2004

Filed:

Feb 13, 2004

Appl. No.:

10/778831

Inventors:

Rebecca Braff - Boston MA, US
Joel Voldman - Somerville MA, US
Martha Gray - Arlington MA, US
Martin Schmidt - Reading MA, US
Mehmet Toner - Wellesley MA, US

International Classification:

C12Q001/04

US Classification:

435/029000, 435/034000, 435/288400

Abstract:

A cell analysis and sorting apparatus is capable of monitoring over time the behavior of each cell in a large population of cells. The cell analysis and sorting apparatus contains individually addressable cell locations. Each location is capable of capturing and holding a single cell, and selectively releasing that cell from that particular location. In one aspect of the invention, the cells are captured and held in wells, and released using vapor bubbles as a means of cell actuation. In another aspect of the invention, the cells are captured, held and released using electric field traps.

US Patent:

20060128006, Jun 15, 2006

Filed:

Jun 7, 2005

Appl. No.:

11/146581

Inventors:

Antimony Gerhardt - Springfield LA, US
Gwendolyn Gerhardt - Springfield LA, US
Rebecca Maxwell - Newton NJ, US
Joel Voldman - Somerville MA, US
Martha Gray - Arlington MA, US
Martin Schmidt - Reading MA, US
Mehmet Toner - Wellesley MA, US

International Classification:

H01L 21/00
C12M 1/34

US Classification:

435287100, 438001000

Abstract:

A cell analysis and sorting apparatus is capable of monitoring over time the behavior of each cell in a large population of cells. The cell analysis and sorting apparatus contains individually addressable cell locations. Each location is capable of capturing and holding a specified number of cells, and selectively releasing that specified number of cells from that particular location. In one aspect of the invention, the cells are captured and held in wells, and released using vapor bubbles as a means of cell actuation. Disclosed are: a cell manipulation apparatus design; various resistive heater configurations for nucleating microbubbles; various well designs, each in communication with a nucleation chamber or channel, for capturing a specified number of cells; and methods of fabrication and cell population manipulation.

US Patent:

20090071831, Mar 19, 2009

Filed:

Feb 4, 2005

Appl. No.:

10/587817

Inventors:

Christopher S. Chen - Princeton NJ, US
Darren Gray - La Jolla CA, US
John Tan - Brentwood CA, US
Joel Voldman - Belmont MA, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

G01N 27/26
C25B 9/06

US Classification:

204547, 204643

Abstract:

The invention provides apparatus and methods for arraying particles on a surface using dielectrophoresis.

US Patent:

20090258383, Oct 15, 2009

Filed:

Aug 27, 2007

Appl. No.:

12/439650

Inventors:

Joseph Kovac - Fort Worth TX, US
Joel Voldman - Belmont MA, US

International Classification:

C12Q 1/02
C12M 1/34
B03B 5/00

US Classification:

435 29, 4352887, 209155

Abstract:

This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose removal or conveyance is desired is defined, and the cell or population is removed or conveyed via application of an optical force and flow-mediated conveyance or removal of the part.

US Patent:

20090294291, Dec 3, 2009

Filed:

Nov 15, 2006

Appl. No.:

12/093763

Inventors:

Joel Voldman - Belmont MA, US
Michael Vahey - Central Valley NY, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

International Classification:

B01D 57/02
B03C 5/00
B03C 5/02

US Classification:

204547, 204643

Abstract:

The present invention is directed to an iso-dielectric separation apparatus for separating particles based upon their electrical properties, and methods of using the apparatus.