John R Didsbury

US Patent:

20090005344, Jan 1, 2009

Filed:

Oct 27, 2005

Appl. No.:

11/718277

Inventors:

James F. Burns - Raleigh NC, US
Leonardo A. Cabana - Cary NC, US
Glenn C. Collupy - Durham NC, US
John R. Didsbury - Raleigh NC, US
Tatyana A. Dyakonov - Durham NC, US
Simon N. Haydar - Newton PA, US
Michael L. Jones - Chapel Hill NC, US
Francine F. Li - Chester Springs PA, US
Christopher J. Markworth - Durham NC, US
Jessymol Mathew - Raleigh NC, US
Frank J. Schoenen - Lawrence KS, US
David S. Van Vliet - Chapel Hill NC, US
David Middlemiss - Bishop's Stortford, GB

Assignee:

NKUADA, LLC - Durham NC

International Classification:

A61K 31/4184
A61K 31/381
A61P 43/00
A61P 29/00
A61P 19/02
A61P 17/06
A61P 19/08
A61P 11/06

US Classification:

514 64, 5483097, 514394, 5483101, 548181, 514365, 548110, 568 6, 5483044, 546 13

Abstract:

Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.

US Patent:

20090264384, Oct 22, 2009

Filed:

Nov 10, 2008

Appl. No.:

12/268237

Inventors:

John R. Didsbury - Raleigh NC, US
Tatyana Dyakonov - Greensboro NC, US
Simon N. Haydar - Newton PA, US
Michael L. Jones - Chapel Hill NC, US
Francine F. Li - Chester Springs PA, US
Christopher J. Markworth - Durham NC, US
Jessy Matthew - Raleigh NC, US
Frank J. Schoenen - Laurence KS, US
Jan J. Scicinski - Mountain View CA, US
David Middlemiss - Bishop's Stortford, GB
James F. Burns - Glen Ridge NJ, US
Leonard A. Cabana - Durham NC, US
Glenn C. Collupy - Durham NC, US
David N. Vanvliet - Chapel Hill NC, US

Assignee:

Nuada, Inc. - Durham NC

International Classification:

A61K 31/69
A61P 1/00
A61P 19/02
A61P 17/06
A61P 11/06
A61P 11/00
A61P 17/00
A61P 37/08

US Classification:

514 64

Abstract:

Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.

US Patent:

20100210695, Aug 19, 2010

Filed:

Jun 19, 2008

Appl. No.:

12/666232

Inventors:

John R. Didsbury - Raleigh NC, US

Assignee:

DARA BIOSCIENCES, INC. - Raleigh NC

International Classification:

A61K 31/44
A61K 31/225
A61P 17/00

US Classification:

514355, 514547

Abstract:

The present invention is directed to pharmaceutical compositions formulated for topical administration comprising an inhibitor of carnitine palmitoyl transferase (CPT1) and methods for treating skin disorders, such as psoriasis, by administration of a CPT1 inhibitor. In particular embodiments, the invention provides a pharmaceutical composition formulated for topical administration comprising the CPT1 inhibitor ST1326. In other embodiments, the invention provides a method of treating a skin disorder, such as psoriasis by administration of the CPT1 inhibitor ST1326.

US Patent:

20110237536, Sep 29, 2011

Filed:

Oct 9, 2009

Appl. No.:

13/122771

Inventors:

John R. Didsbury - Raleigh NC, US
Kenneth J. Ingold - Durham NC, US
Linda Goff Jet - Hillsborough NC, US
Andrew Xian Chen - San Diego CA, US
Hailiang Chen - San Diego CA, US

International Classification:

A61K 31/7076
A61P 29/00
A61P 25/04
B82Y 5/00

US Classification:

514 45, 977773, 977915

Abstract:

The present invention relates to the use of spicamycin derivatives for treatment and/or prevention of pain, including neuropathic pain. The invention further relates to pharmaceutical compositions of spicamycin derivatives suitable for treatment or prevention of pain.

US Patent:

20080319044, Dec 25, 2008

Filed:

Oct 27, 2005

Appl. No.:

11/718286

Inventors:

John R. Didsbury - Raleigh NC, US
Tatyana A. Dyakonov - Durham NC, US
Simon N. Haydar - Newton PA, US
Michael L. Jones - Chapel Hill NC, US
Francine F. Li - Chester Springs PA, US
Christopher J. Markworth - Durham NC, US
Jessymol Mathew - Raleigh NC, US
Frank J. Schoenen - Lawrence KS, US
Jan J. Scicinski - Sunnyvale CA, US
David Middlemiss - Bishop's Stortford, GB

Assignee:

NUADA, LLC - Durham NC

International Classification:

A61K 31/404
C07D 209/04
A61P 1/00
A61P 19/02
A61P 17/06
A61P 25/28
A61P 9/00
A61P 3/10
A61P 35/00
A61P 9/12
A61P 15/10

US Classification:

514415, 548491

Abstract:

Indole boronic acid compounds, and analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof.

US Patent:

20210369680, Dec 2, 2021

Filed:

Apr 29, 2021

Appl. No.:

17/244226

Inventors:

- Research Triangle Park NC, US
John DIDSBURY - Raleigh NC, US

International Classification:

A61K 31/421
A61K 31/675
A61K 31/167
A61K 31/4965
A61K 31/155
A61K 31/245
A61K 31/519
A61K 31/4178
A61K 39/395
A61P 31/14

Abstract:

This disclosure describes the use of indane acetic acid derivatives which are PPAR agonists, including PPAR delta, PPAR gamma, and dual PPAR delta and gamma agonists, and which penetrate the blood brain barrier to achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of betacoronavirus diseases, such as COVID-19 and COVID-19 related co-morbid diseases, including Acute Respiratory Distress and CNS disorders, such as delirium and cognitive impairment.

US Patent:

20180153859, Jun 7, 2018

Filed:

Dec 2, 2016

Appl. No.:

15/367344

Inventors:

- Research Triangle Park NC, US
John R. Didsbury - Raleigh NC, US

Assignee:

T3D Therapeutics, Inc. - Research Triangle Park NC

International Classification:

A61K 31/421
A61K 45/06
A61K 31/192
A61K 31/426
C12Q 1/68

Abstract:

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

US Patent:

20180153860, Jun 7, 2018

Filed:

Dec 2, 2016

Appl. No.:

15/367396

Inventors:

- Research Triangle Park NC, US
John R. Didsbury - Raleigh NC, US

Assignee:

T3D Therapeutics, Inc. - Research Triangle Park NC

International Classification:

A61K 31/421
A61K 45/06
A61K 31/192

Abstract:

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders.