Atwood Kim CHEUNG - Arlington MA, US Donovan Noel CHIN - Lexington MA, US Natalie DALES - Arlington MA, US Aleem FAZAL - Burlington MA, US Timothy Brian HURLEY - Boston MA, US John KERRIGAN - Wakefield MA, US Gary O'BRIEN - Maynard MA, US Lei SHU - Woburn MA, US Robert SUN - Natick MA, US Moo Je SUNG - Belmont MA, US
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
3-(5-Methoxy-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione Derivatives And Uses Thereof
- Basel, CH Jennifer Stroka COBB - Stow MA, US Natalie DALES - Arlington MA, US John Ryan KERRIGAN - Wakefield MA, US Philip LAM - Somerville MA, US Hasnain Ahmed MALIK - Boston MA, US Gary O'BRIEN - Maynard MA, US Andrew W. PATTERSON - Somerville MA, US Noel Marie-France THOMSEN - Chelmsford MA, US Pamela TING - Cambridge MA, US
The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
- Basel, CH Donovan Noel CHIN - Lexington MA, US Natalie DALES - Arlington MA, US Aleem FAZAL - Wilmington MA, US Timothy Brian HURLEY - Boston MA, US John KERRIGAN - Wakefield MA, US Gary O'BRIEN - Maynard MA, US Lei SHU - Lexington MA, US Robert SUN - Natick MA, US Moo Je SUNG - Belmont MA, US
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
- Basel, CH Jennifer Stroka Cobb - Stow MA, US Natalie Alysia Dales - Arlington MA, US Janetta Dewhurst - Framingham MA, US Matthew James Hesse - Oakland CA, US Rama Jain - Danville CA, US John Ryan Kerrigan - Wakefield MA, US Hasnain Ahmed Malik - Boston MA, US James R. Manning - Emeryville CA, US Gary O'Brien - Maynard MA, US Andrew W. Patterson - Somerville MA, US Noel Marie-France Thomsen - Chelmsford MA, US Pamela YF TING - Somerville MA, US
International Classification:
C07D 403/14 C07D 405/14 C07D 417/14 A61P 7/00
Abstract:
The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
3-(5-Oxy)-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione Derivatives And Uses Thereof
- Basel, CH Jennifer Stroka Cobb - Stow MA, US Janetta Dewhurst - Framingham MA, US John Ryan Kerrigan - Wakefield MA, US Gary O'Brien - Maynard MA, US Noel Marie-France Thomsen - Chelmsford MA, US Pamela Ting - Somerville MA, US
The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
- Basel, CH Donovan Noel CHIN - Lexington MA, US Natalie DALES - Arlington MA, US Aleem FAZAL - Burlington MA, US Timothy Brian HURLEY - Boston MA, US John KERRIGAN - Wakefield MA, US Gary O'BRIEN - Maynard MA, US Lei SHU - Lexington MA, US Robert SUN - Natick MA, US Moo Je SUNG - Belmont MA, US
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
1,4-Disubstituted Pyridazine Analogs There Of And Methods For Treating Smn-Deficiency-Related Conditions
- Basel, CH Donovan Noel CHIN - Lexington MA, US Natalie DALES - Arlington MA, US Aleem FAZAL - Burlington MA, US Timothy Brian HURLEY - Boston MA, US John KERRIGAN - Wakefield MA, US Gary O'BRIEN - Maynard MA, US Lei SHU - Woburn MA, US Robert SUN - Natick MA, US Moo Je SUNG - Belmont MA, US
The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
The present disclosure provides a compound of formula (I):or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
Name / Title
Company / Classification
Phones & Addresses
John F. Kerrigan Owner
John F Kerrigan Atty Legal Services, Nsk
294 N Washington St, Boston, MA 02114
John Kerrigan Managing
H.S.H. Agency Management LLC
John T. Kerrigan Director
LUPUS FOUNDATION OF NEW ENGLAND, INC Business Services
40 Speen St SUITE 101, Framingham, MA 01701 5088725200
John M. Kerrigan Vice-Chairman
Braintree Housing Authority Housing Program · Real Estate Agents
25 Roosevelt St, Braintree, MA 02184 7818481484
John J. Kerrigan President
KICKA'S INN, INC
33 Myrtle Ave, Winthrop, MA 02152 68 Post Is Rd, Quincy, MA
John P. Kerrigan Clerk
FUSILIER VETERAN CORPS OF MASSACHUSETTS
11 Main St, Winchester, MA 01890 65 Rockland Ave, Malden, MA 02148
Phoenix Childrens Hospital Neurology 1919 E Thomas Rd Amblutory Bldg, Phoenix, AZ 85016 6025460970 (phone), 6029334254 (fax)
District Medical GroupChildrens Rehabilitative Services Primary Care Clinic 3141 N 3 Ave STE 100, Phoenix, AZ 85013 6029141520 (phone), 6022660545 (fax)
Phoenix Childrens Hospital Neurology 1919 E Thomas Rd FL 3, Phoenix, AZ 85016 6029330970 (phone), 6029334254 (fax)
Education:
Medical School University of California, San Francisco School of Medicine Graduated: 1983
Procedures:
Sleep and EEG Testing Neurological Testing
Conditions:
Epilepsy Bell's Palsy Hemorrhagic stroke Infectious Diseases of the Brain or Spinal Cord Insomnia
Languages:
English Spanish
Description:
Dr. Kerrigan graduated from the University of California, San Francisco School of Medicine in 1983. He works in Phoenix, AZ and 2 other locations and specializes in Child Neurology and Neurophysiology, Clinical. Dr. Kerrigan is affiliated with Kindred Hospital-Phoenix and Phoenix Childrens Hospital.
Franciscan Medical GroupFranciscan Anesthesia Associates 11315 Bridgeport Way SW, Lakewood, WA 98499 2535302224 (phone), 2535302226 (fax)
Education:
Medical School St. George's University School of Medicine, St. George's, Greneda Graduated: 1987
Procedures:
Breast Reconstruction Hernia Repair
Conditions:
Abdominal Hernia
Languages:
English
Description:
Dr. Kerrigan graduated from the St. George's University School of Medicine, St. George's, Greneda in 1987. He works in Lakewood, WA and specializes in Anesthesiology. Dr. Kerrigan is affiliated with Saint Clare Hospital.
Carpenter Avenue Elementary School Studio City CA 1972-1976, Highlander Road School West Hills CA 1976-1978, Katherine Elementary School Simi Valley CA 1978-1979