John H Streiff

US Patent:

20120065247, Mar 15, 2012

Filed:

Mar 26, 2010

Appl. No.:

13/259503

Inventors:

Sunnie R. Thompson - Birmingham AL, US
Erik Mills Schwiebert - Birmingham AL, US
John H. Streiff - Birmingham AL, US

Assignee:

DiscoveryBiomed, Inc. - Birmingham AL
The UAB Research Foundation - Birmingham AL

International Classification:

A61K 31/7088
C07C 235/56
C07D 277/46
C07D 213/46
C07C 217/60
C07D 231/12
A61K 31/44
A61K 31/4406
A61K 31/426
A61K 31/415
A61K 31/167
A61K 31/137
A61K 31/713
A61P 31/14
A61P 31/22
A61P 31/20
C12N 5/071
A61P 35/00
C12Q 1/02
C12Q 1/68
C12Q 1/70
C12Q 1/66
A61K 31/4402
C07D 213/75

US Classification:

514 44 A, 546309, 564176, 548195, 546338, 546285, 564336, 5483771, 514352, 514357, 514371, 514406, 514622, 514649, 435375, 435 29, 435 613, 435 5, 435 611, 435 8

Abstract:

Provided herein are compounds and methods for use in preventing or treating a viral infection mediated by a virus comprising an IRES-containing RNA molecule or cancer related to an increase or decrease in IRES-mediated translation of an RNA molecule. Also provided are methods of inhibiting or promoting IRES-mediated translation. Also provided are methods of screening for an agent that inhibits IRES-mediated translation.

US Patent:

20220331431, Oct 20, 2022

Filed:

Sep 9, 2020

Appl. No.:

17/641853

Inventors:

- Philadelphia PA, US
John H. Streiff - Birmingham AL, US
Peihua Jiang - Clarksville MD, US
Paul A.S. Breslin - Pittsburgh PA, US

International Classification:

A61K 47/22
A61K 45/06

Abstract:

Provided herein are compositions and methods of ameliorating the pharmaceutical aversiveness of active pharmaceutical ingredient (API) by administering the API after or substantially simultaneously with a flavone compound.

US Patent:

20160038475, Feb 11, 2016

Filed:

Mar 14, 2014

Appl. No.:

14/775050

Inventors:

- Birmingham AL, US
John Streiff - Birmingham AL, US
John Dixon - Leicestershire, GB
Hongwu Gao - Shanghai, CN
Joseph P. Ritchie - Vestavia Hills AL, US
Eric C. Seales - Birmingham AL, US
Deborah Mai - Birmingham AL, US

Assignee:

DISCOVERYBIOMED, INC. - Birmingham AL

International Classification:

A61K 31/4709
A61K 31/422
A61K 31/4439
A61K 31/427

Abstract:

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell.

US Patent:

20160024065, Jan 28, 2016

Filed:

Mar 14, 2014

Appl. No.:

14/775010

Inventors:

- Birmingham AL, US
John Streiff - Birmingham AL, US
John Dixon - Leicestershire, GB
Hongwu Gao - Shanghai, CN

Assignee:

DISCOVERYBIOMED, INC. - Birmingham AL

International Classification:

C07D 417/04
C07D 417/14
C07D 413/04

Abstract:

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.

US Patent:

20150307503, Oct 29, 2015

Filed:

Nov 20, 2013

Appl. No.:

14/646092

Inventors:

- Birmingham AL, US
John Streiff - Birmingham AL, US
John Dixon - Leicestershire, GB
Hongwu Gao - Shanghai, CN

Assignee:

DISCOVERYBIOMED, INC. - Birmingham AL

International Classification:

C07D 487/14
C07D 473/08
C07D 498/14

Abstract:

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.

US Patent:

20150299206, Oct 22, 2015

Filed:

Nov 20, 2013

Appl. No.:

14/646063

Inventors:

- Birmingham AL, US
John Streiff - Birmingham AL, US
John Dixon - Leicestershire, GB
Hongwu Gao - Shanghai, CN

Assignee:

DISCOVERYBIOMED, INC. - Birmingham AL

International Classification:

C07D 487/04
C07D 498/04
C07D 471/04

Abstract:

Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.