Justin B Leong

Address:

87 Ledyard St, San Francisco, CA 94124

VIN:

WBAVB73557FV75358

Make:

BMW

Model:

3-Series 4dr Sdn 335i RW

Year:

2007

US Patent:

20200179431, Jun 11, 2020

Filed:

Oct 21, 2019

Appl. No.:

16/659093

Inventors:

- BERKELEY CA, US
David Kanne - Corte Madera CA, US
Leonard Sung - San Mateo CA, US
Kelsey Gauthier - Alameda CA, US
Laura Hix Glickman - Oakland CA, US
Justin Leong - Union City CA, US
Sarah M. McWhirter - Albany CA, US

Assignee:

ADURO BIOTECH, INC. - BERKELEY CA

International Classification:

A61K 31/7084
C07H 19/213
A61K 39/39
A61P 35/00
A61P 3/10
A61P 29/00
A61P 11/06
A61P 37/06
C07H 21/02
C07H 21/00

Abstract:

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′ CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.