Justin J Leong

US Patent:

20210011518, Jan 14, 2021

Filed:

Apr 24, 2019

Appl. No.:

16/651545

Inventors:

- Mountain View CA, US
Christen Cameron BILGER - Sunnyvale CA, US
Frederic Heckmann - Mountain View CA, US
Frances KWEE - Redwood City CA, US
Justin LEONG - Milpitas CA, US
James CASTRO - San Jose CA, US

International Classification:

G06F 1/16
H04R 1/02
H04R 1/34

Abstract:

This application is directed to a speaker assembly in which a speaker is mounted in an enclosure structure. The enclosure structure exposes a speaker opening of the speaker and provides a sealed enclosure for a rear portion of the speaker, and further includes an electrically conductive portion. One or more electronic components are coupled to the electrically conductive portion of the enclosure structure (which is grounded in some implementations). The electrically conductive portion of the enclosure structure is configured to provide electromagnetic shielding for the electronic components and forms part of the sealed enclosure of the speaker. In some implementations, the electrically conductive portion of the enclosure structure is thermally coupled to the electronic components and acts as a heat sink that is configured to absorb heat generated by the electronic components and dissipate the generated heat away from the electronic components.

US Patent:

20200179431, Jun 11, 2020

Filed:

Oct 21, 2019

Appl. No.:

16/659093

Inventors:

- BERKELEY CA, US
David Kanne - Corte Madera CA, US
Leonard Sung - San Mateo CA, US
Kelsey Gauthier - Alameda CA, US
Laura Hix Glickman - Oakland CA, US
Justin Leong - Union City CA, US
Sarah M. McWhirter - Albany CA, US

Assignee:

ADURO BIOTECH, INC. - BERKELEY CA

International Classification:

A61K 31/7084
C07H 19/213
A61K 39/39
A61P 35/00
A61P 3/10
A61P 29/00
A61P 11/06
A61P 37/06
C07H 21/02
C07H 21/00

Abstract:

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′ CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.

US Patent:

20200110441, Apr 9, 2020

Filed:

Oct 8, 2019

Appl. No.:

16/596711

Inventors:

- Mountain View CA, US
Carl CEPRESS - Los Altos CA, US
Chih-min CHIEN - Taipei City, TW
Liang CHENG - Fremont CA, US
Justin LEONG - Milpitas CA, US
Xiaoping QIN - San Jose CA, US

International Classification:

G06F 1/16
G02F 1/1333
G02F 1/1337

Abstract:

In a display assistant device, a display panel assembly has a plurality of first retention elements, and each first retention element is formed on a rear surface of the display panel assembly and adjacent to a respective first edge of the display panel assembly. A back cover is configured to hold the display panel assembly using a plurality of second retention elements. Each second retention element is arranged adjacent to a respective second edge of the back cover. When mated to each other, the first and second retention elements are configured to control an in-plane displacement of each second edge of the back cover in response to an impact of a force on the second edges, thereby limiting an out-of-plane displacement of each second edge of the back cover and protecting the first edges of the display panel assembly from falling apart from the second edges of the back cover.

US Patent:

20190062365, Feb 28, 2019

Filed:

Oct 28, 2016

Appl. No.:

15/771286

Inventors:

- Berkeley CA, US
- Basel, CH
Leonard SUNG - San Mateo CA, US
Kelsey GAUTHIER - Alameda CA, US
Laura Hix GLICKMAN - Oakland CA, US
Justin LEONG - Union City CA, US
Sarah M. McWHIRTER - Albany CA, US
Jeffrey McKENNA - Carlisle MA, US
Stephen M. CANHAM - Cambridge MA, US
Chudi Obioma NDUBAKU - Oakland CA, US

Assignee:

ADURO BIOTECH, INC. - Berkeley CA
NOVARTIS AG - Basel

International Classification:

C07H 21/04
C07H 21/02
A61K 45/06
A61K 39/39
A61P 35/00
A61K 39/395

Abstract:

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.

US Patent:

20180369268, Dec 27, 2018

Filed:

Dec 16, 2016

Appl. No.:

16/062601

Inventors:

- Berkeley, CA
David KANNE - Corte Madera CA, US
Leonard SUNG - San Mateo CA, US
Justin LEONG - Union City CA, US
Sarah M. McWHIRTER - Albany CA, US

Assignee:

ADURO BIOTECH, INC. - BERKELEY CA

International Classification:

A61K 31/7084
G01N 33/50
A61K 45/06
A61K 39/39
A61K 35/17
C07D 307/04
C07D 273/02

Abstract:

The present invention relates to the use cyclic-di-nucleotide and related scaffold molecules that measurably inhibit STING signaling, and methods for their use in identifying more potent inhibitors of STING signaling. In particular, the methods provided can be used to identify potent inhibitors of STING signaling, which are useful in the treatment of autoimmune and inflammatory diseases. Also provided are compounds having STING inhibitory activity useful in the treatment of autoimmune and inflammatory diseases.

US Patent:

20180064745, Mar 8, 2018

Filed:

Mar 9, 2016

Appl. No.:

15/556982

Inventors:

- BERKELEY CA, US
David Kanne - Corte Madera CA, US
Leonard Sung - San Mateo CA, US
Kelsey Gauthier - Alameda CA, US
Laura Hix Glickman - Oakland CA, US
Justin Leong - Union City CA, US
Sarah M. McWhirter - Albany CA, US

Assignee:

ADURO BIOTECH, INC. - BERKELEY CA

International Classification:

A61K 31/7084
A61K 39/39
C07H 19/213

Abstract:

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.