Kenneth L Rhodes

US Patent:

6361971, Mar 26, 2002

Filed:

Sep 21, 1999

Appl. No.:

09/399913

Inventors:

Kenneth Rhodes - Neshanic Station NJ
Maria Betty - Mt. Laurel NJ
Huai-Ping Ling - Princeton Junction NJ
Wenqian An - Framingham MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
American Home Products Corporation - Madison NJ

International Classification:

C12N 1512

US Classification:

435 691, 4353201, 435325, 536 235

Abstract:

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

US Patent:

6369197, Apr 9, 2002

Filed:

Apr 23, 1999

Appl. No.:

09/298731

Inventors:

Kenneth Rhodes - Neshanic Station NJ
Maria Betty - Moorestown NJ
Huai-Ping Ling - Princeton Junction NJ
Wengian An - Framingham MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
American Home Products Corp. - Madison NJ

International Classification:

C07K 1400

US Classification:

530350, 530324

Abstract:

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

US Patent:

6689581, Feb 10, 2004

Filed:

Jul 9, 1999

Appl. No.:

09/350614

Inventors:

Kenneth Rhodes - Neshanic Station NJ
Maria Betty - Mt. Laurel NJ
Huai-Ping Ling - Princeton Junction NJ
Wenqian An - Framingham MA

Assignee:

Wyeth - Madison NJ
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 1512

US Classification:

435 691, 4353201, 435325, 536 235

Abstract:

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

US Patent:

7041795, May 9, 2006

Filed:

Apr 8, 2002

Appl. No.:

10/118590

Inventors:

Kenneth Rhodes - Neshanic Station NJ, US
Maria Betty - Moorestown NJ, US
Huai-Ping Ling - Princeton Junction NJ, US
Wengian An - Framingham MA, US

Assignee:

Millennium Pharmaceuticals, Inc - Cambridge MA
Wyeth - Madison NJ

International Classification:

C07K 14/00
C12N 15/00
C12N 15/12
C12N 15/63
C12Q 1/68

US Classification:

530350, 435 691, 435325, 4353201, 435 6

Abstract:

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

US Patent:

7049083, May 23, 2006

Filed:

Jan 17, 2002

Appl. No.:

10/051843

Inventors:

Kathleen H. Young - Newtown PA, US
Kenneth J. Rhodes - Neshanic Station NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12N 15/63
C12N 1/15
C12N 1/16
C12N 15/00
G01N 33/566

US Classification:

435 72, 4353201, 435325, 4351731, 4352523, 4352542

Abstract:

Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.

US Patent:

7049094, May 23, 2006

Filed:

Jan 17, 2002

Appl. No.:

10/051841

Inventors:

Kathleen H. Young - Newtown PA, US
Kenneth J. Rhodes - Neshanic Station NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12N 15/00
C12N 15/12
C12N 15/63
C07K 14/00
C07H 21/04

US Classification:

435 691, 4353201, 435325, 4241921, 4241851, 536 235, 530350

Abstract:

Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.

US Patent:

7078481, Jul 18, 2006

Filed:

Sep 27, 2000

Appl. No.:

09/670756

Inventors:

Kenneth Rhodes - Neshanic Station NJ, US
Maria Betty - Mt. Laurel NJ, US
Huai-Ping Ling - Princeton Junction NJ, US
Wenqian An - Wayland MA, US

Assignee:

Wyeth - Madison NJ
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K 14/00
C07K 14/435

US Classification:

530350, 530300

Abstract:

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

US Patent:

7115381, Oct 3, 2006

Filed:

Sep 21, 1999

Appl. No.:

09/400492

Inventors:

Kenneth Rhodes - Neshanic Station NJ, US
Wenqian An - Framingham MA, US

International Classification:

C12N 15/12
C12N 15/63
C12N 15/00
G01N 33/566
G01N 33/53

US Classification:

435 72, 435 691, 4353201, 435325, 435 78, 530350

Abstract:

The invention provides methods for identifying compounds suitable for treating a cardiovascular disorder, as well as methods for treating a cardiovascular disorder. The invention also provides methods for determining if a subject is at risk for a cardiovascular disorder.