12555 Caminito De La Gallarda, San Diego, CA 92128
Industry:
Research
Work:
Padlock Therapeutics
Director of Biology
The Scripps Research Institute 2005 - Dec 2015
Associate Professor
Padlock Therapeutics 2005 - Dec 2015
Cofounder and Consultant
First In Science Jan 1, 2013 - 2014
Consultant
Harvard University Oct 1, 2000 - Dec 1, 2004
Postdoctoral Fellow
Education:
Uc San Diego 1996 - 2000
Southern Illinois University, Carbondale 1992 - 1996
Bachelors, Bachelor of Arts, Biology
Porta High School 1986 - 1994
Skills:
Cell Biology Molecular Biology Biochemistry Cell Culture Cell Life Sciences Immunology Protein Chemistry Flow Cytometry Drug Discovery Western Blotting Genetics Pcr Cancer Lifesciences Molecular Cloning Animal Models In Vivo Science Protein Expression Protein Purification Sonication
Us Patents
Modulation Of Immune System Function By Modulation Of Polypeptide Arginine Methyltransferases
The instant invention pertains to, e.g., method of identifying a compound that modulates cytokine production or T cell receptor-mediated signaling, by identifying modulators of the expression and/or activity or PRMT polypeptides. The invention further pertains to methods for identifying a compound that modulates cytokine production in a non-T cell, by identifying compounds that modulate the expression and/or activity of NIP45. Methods for modulating cytokine production in cells by modulating the expression and/or activity of at least one molecule selected from the group consisting of: NIP45, PRMT1, and NFAT are also provided. The invention also pertains to methods for modulating the relative number of Th1 or Th2 cells is modulated and to methods of treating a subject that would benefit from the modulation of cytokine production comprising contacting an immune cell from the subject with an agent that modulates PRMT 1 expression and/or activity in the immune cell.