Kristen L Moffat

US Patent:

20100292791, Nov 18, 2010

Filed:

Aug 12, 2009

Appl. No.:

12/583072

Inventors:

Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US

International Classification:

A61F 2/08
A61K 35/32
A61K 38/18
A61P 19/02
A61K 38/22
A61P 29/00
A61P 31/00
A61P 35/00
A61P 37/06
A61K 38/06
B29C 65/02

US Classification:

623 1312, 424426, 424 937, 514 76, 514 97, 514 171, 623 1314, 1563046

Abstract:

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

US Patent:

20110066242, Mar 17, 2011

Filed:

Aug 24, 2010

Appl. No.:

12/806912

Inventors:

Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US

International Classification:

A61F 2/08
A61F 2/02

US Classification:

623 1314, 623 2372

Abstract:

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.

US Patent:

20100047309, Feb 25, 2010

Filed:

Jun 6, 2009

Appl. No.:

12/455765

Inventors:

Helen H. Lu - New York NY, US
Jeffrey P. Spalazzi - Staten Island NY, US
Moira C. Vyner - Greenwich CT, US
Kristen L. Moffat - Oakmont PA, US

International Classification:

A61F 2/08
A61K 38/18
A61K 35/00
A61K 35/32
C08J 5/00

US Classification:

424423, 623 1314, 514 12, 424 937, 26433111

Abstract:

This application describes apparatuses and methods for musculoskeletal tissue engineering. Specifically, graft collar and scaffold apparatuses are provided for promoting fixation of musculoskeletal soft tissue to bone.This application provides for graft collars comprising biopolymer mesh and/or polymer-fiber mesh for fixing tendon to bone. In one aspect, the graft collar comprises more than one region, wherein the regions can comprise different materials configured to promote integration of and the regeneration of the interfacial region between tendon and bone.This application also provides for scaffold apparatuses and methods for fixing musculoskeletal soft tissue to bone. The scaffold apparatus is multiphasic, preferably triphasic, and each phase is configured promote growth and proliferation of a different cell and its associated tissue. In one aspect, the scaffold apparatus is triphasic, with phases comprising materials to promote growth and proliferation of fibroblasts, chondroblasts, and osteoblasts. In addition, an apparatus comprising two portions, each of said portion being the scaffold apparatus described above is provided, wherein each of said portion encases one end of a soft tissue graft. Further, a triphasic interference screw is provided.This application further provides apparatuses and methods for inducing formation of fibrocartilage comprising wrapping a graft collar with polymer-fiber mesh configured to apply compression to the graft collar. In another aspect, the polymer-fiber is applied directly to the graft to apply compression to the graft.

US Patent:

20150100121, Apr 9, 2015

Filed:

Sep 30, 2014

Appl. No.:

14/503053

Inventors:

Helen H. Lu - New York NY, US
Jeffrey Spalazzi - Staten Island NY, US
Kristen L. Moffat - Oakmont PA, US
William N. Levine - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61F 2/08
A61L 27/18

US Classification:

623 1312

Abstract:

An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also provided is a fully synthetic implantable multiphased scaffold which includes, in a single continuous construct, a plurality of phases to mimic the natural anatomy of a tendon or ligament and their insertion sites. Also provided are scaffold apparatuses for musculoskeletal tissue engineering.