Leonid Z Iakoubov

US Patent:

7368243, May 6, 2008

Filed:

Jul 8, 2005

Appl. No.:

11/178246

Inventors:

Ekkehard Schuetz - Gottingen, DE
Leonid Iakoubov - San Ramon CA, US
Howard Urnovitz - Iowa City IA, US

Assignee:

Chronix Biomedical - San Jose CA

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/02
C07H 21/04

US Classification:

435 6, 435 912, 536 231, 536 243

Abstract:

The present invention provides a method of detecting abnormal serum nucleic acid profiles to assess the risk of a transmissible spongiform encephalopathy, e. g. , BSE.

US Patent:

20020120109, Aug 29, 2002

Filed:

Jul 6, 2001

Appl. No.:

09/900309

Inventors:

Gennady Samokhin - Lincoln Park NJ, US
Vladimir Torchilin - Charlestown MA, US
Leonid Iakoubov - Pleasanton CA, US
Dmitriy Mongayt - Swampscott MA, US

International Classification:

C12P021/06
C07K016/46
C07K014/00

US Classification:

530/391100, 530/395000, 435/068100

Abstract:

Methods are disclosed for preparing biologically active protein conjugates using negatively charged polymers that protect the protein within the conjugate so that it retains a substantial amount of its biological activity following conjugation (e.g., procedure in which a protein is conjugated to a pharmaceutical agent, a solid support, a reporter molecule, a group carrying a reporter molecule, an acylating agent, a chelating agent, a cross-linking agent, a targeting group, and a ligand and binding group). The invention also includes novel protein conjugates prepared by those methods.

US Patent:

20030036077, Feb 20, 2003

Filed:

May 31, 2002

Appl. No.:

10/161101

Inventors:

Alex Chenchik - Palo Alto CA, US
Leonid Iakoubov - Pleasanton CA, US
Howard Urnovitz - San Francisco CA, US

Assignee:

Chronix Biomedical - Benecia CA

International Classification:

C12Q001/68
C07H021/02
C12P019/34

US Classification:

435/006000, 536/023100, 536/024300, 435/091200

Abstract:

Methods for generating an mRNA expression profile are provided. In the subject methods, a population of nucleic acid targets is first generated from an acellular blood sample that contains a plurality of distinct mRNAs, i.e., a disease specific particular blood fraction. The resultant nucleic acid targets are hybridized to an array of nucleic acid probes to obtain an mRNA expression profile. The subject mRNA expression profiles are useful in the identification of disease specific markers. In such applications, the mRNA expression profiles are compared to a control expression profile to identify disease specific markers, where the identified markers subsequently find use in diagnostic applications. The subject methods also find use in diagnostic applications, where the mRNA expression profile is compared to a reference in making a diagnosis of the presence of a disease condition. Finally, kits for use in practicing the various methods are provided.

US Patent:

20060099621, May 11, 2006

Filed:

Oct 7, 2005

Appl. No.:

11/245514

Inventors:

Ekkehard Schuetz - Gottingen, DE
Leonid Iakoubov - Pleasanton CA, US
Howard Urnovitz - Iowa City IA, US

Assignee:

Chronix Biomedical - San Jose CA

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

The present invention provides a method of detecting abnormal circulating nucleic acid profiles to assess the risk of Creutzfeldt-Jakob Disease.

US Patent:

20130195880, Aug 1, 2013

Filed:

Aug 5, 2010

Appl. No.:

13/388271

Inventors:

Leonid Z. Iakoubov - San Ramon CA, US
Henry Wilfred Lopez - Napa CA, US
Steven Patrick Noonan - Alameda CA, US

International Classification:

C12Q 1/68

US Classification:

4241431, 435 611, 536 2431

Abstract:

Provided are methods and kits to determine whether a subject is predisposed to developing a disease or condition associated with structural polymorphisms in genes CNTNAP2 and CNTNAP4, along with the methods to optimize treatment with various pharmaceutical preparations which modulate ion channels, neurite outgrowth, and myelination signaling.