Leslie K Chun from Soquel, CA, age 62

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Transdermal Therapeutic Systems For The Administration Of Naloxone, Naltrexone And Nalbuphine
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US Patent:

45739951, Mar 4, 1986
Filed:

Oct 9, 1984
Appl. No.:

6/659122
Inventors:

Yu-Ling Chen - Cupertino CA
Leslie L. Chun - Palo Alto CA
David J. Enscore - Sunnyvale CA
Assignee:

ALZA Corporation - Palo Alto CA
International Classification:

A61K 900
US Classification:

604896
Abstract:

A method for transdermal delivery of naloxone, naltrexone and nalbuphine base through intact skin is described. Preferred embodiments of transdermal therapeutic systems for delivering these drugs and polyethylene glycol monolaurate employ an ethylene vinylacetate matrix containing drug base at a concentration above saturation and polyethylene glycol monolaurate below unit activity. Polyethylene glycol manolaurate is disclosed as a permeation enhancer for the base form of these drugs and is preferably delivered simultaneously with the drug.