Lilia Z Topol

US Patent:

20030078406, Apr 24, 2003

Filed:

Dec 27, 2001

Appl. No.:

10/033717

Inventors:

Donald Blair - Frederick MD, US
Peter Clausen - Frederick MD, US
Lilia Topol - Frederick MD, US
Maria Marx - L'Hay Les Roses, FR
Georges Calothy - Orsay, FR

Assignee:

The Government of the U.S.A., as represented by the Secretary, Dept. of Health & Human Services

International Classification:

C07K014/705
C07H021/04
C12P021/02
C12N005/06

US Classification:

536/023500, 530/350000, 435/069100, 435/325000, 435/320100

Abstract:

The present invention provides an isolated nucleic acid encoding DRM protein, an isolated DRM polypeptide, and a fusion polypeptide comprising a DRM protein and a green fluorescent protein. The present invention also provides a method of arresting the growth of a cell, comprising administering to the cell an effective amount of DRM protein or an active fragment thereof; a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to the subject an effective amount of DRM protein or an active fragment thereof, in a pharmaceutically acceptable carrier. In addition, the present invention provides a method of arresting growth of a cell, comprising administering to the cell an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof, a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to a cell of the subject, in a pharmaceutically acceptable carrier, an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof, under conditions whereby the nucleic acid is expressed in the subject's cell.