Lori J Manzel from 3316 Timber Valley Ct, Cedar Rapids, IA 52402, age 61, Phone: 3193950644

Antagonism Of Immunostimulatory Cpg-Oligonucleotides By 4-Aminoquinolines And Other Weak Bases
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US Patent:

6479504, Nov 12, 2002
Filed:

Jun 16, 2000
Appl. No.:

09/595875
Inventors:

Donald E. Macfarlane - Iowa City IA
Lucjan Strekowski - Stone Mountain GA
Lori Manzel - Cedar Rapids IA
Fyaz M. D. Ismail - Stockton on Tees, GB
Gordon B. Barlin - Turner, AU
Assignee:

The University of Iowa Research Foundation - Iowa City IA
Georgia State University Research Foundation, Inc. - Atlanta GA
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:

A61K 3144
US Classification:

514297, 514312, 514313, 546105, 546159, 546160
Abstract:

The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.

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Lori J Manzel