A cuvette cartridge for optical measurements is disclosed herein, the cartridge comprising a flat, adhesive sheet having a selected thickness that defines an optical path length perpendicular to the longitudinal axis of such sheet; wherein a portion of the adhesive sheet is cut out to define at least one optical chamber of a desired length; wherein the adhesive sheet is placed between a first flat sheet and a second flat sheet, the first flat sheet comprising at least one inlet hole and at least one outlet hole, the vent hole being located at a first end of the optical chamber and the inlet hole being located at a second end of the optical chamber. An integrated analytical system employing this cartridge and optionally including a vacuum chuck for holding and registering the cartridge are also disclosed.
Optical Architectures For Microvolume Laser-Scanning Cytometers
Louis J. Dietz - Mountain View CA Ian Walton - Redwood City CA Scott Norton - Sunnyvale CA
Assignee:
SurroMed, Inc. - Mountain View CA
International Classification:
G01J 330
US Classification:
356 39, 356317, 356417, 2504581
Abstract:
Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).
Louis J. Dietz - Mountain View CA Ian Walton - Redwood City CA Chih-Hua Chung - Fremont CA Scott Norton - Sunnyvale CA James L. Winkler - Sunnyvale CA Aaron B. Kantor - Newark CA Byron Lee - San Jose CA Shalom Tsur - Mountain View CA
Assignee:
SurroMed, Inc. - Mountain View CA
International Classification:
G06K 900
US Classification:
382133, 359201
Abstract:
The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.
Method Of Manufacture Of Colloidal Rod Particles As Nanobar Codes
Michael J. Natan - Los Altos CA Thomas E. Mallouk - State College PA Benjamin R. Martin - State College PA Brian D. Reiss - State College PA Louis J. Dietz - Mountain View CA James L. Winkler - Sunnyvale CA
Assignee:
Surromed, Inc. - Menlo Park CA
International Classification:
C25D 502
US Classification:
205118, 205122
Abstract:
Synthetic methods for the manufacture of segmented nanoparticles are described.
Optical Architectures For Microvolume Laser-Scanning Cytometers
Louis J. Dietz - Mountain View CA Ian Walton - Mountain View CA Scott Norton - Sunnyvale CA
Assignee:
SurroMed, Inc. - Menlo Park CA
International Classification:
G01N 2164
US Classification:
2504581, 2504591, 356317, 356318
Abstract:
Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).
Method Of Manufacture Of Colloidal Rod Particles As Nanobarcodes
Walter Stonas - Campbell CA, US Louis J. Dietz - Mountain View CA, US Ian D. Walton - Redwood City CA, US Michael J. Natan - Los Altos CA, US James L. Winkler - Sunnyvale CA, US
Assignee:
Nanoplex Technologies, Inc. - Menlo Park CA
International Classification:
C25D005/02
US Classification:
205 74, 205 76, 205122, 205131
Abstract:
A method is disclosed for the manufacture of colloidal rod particles as nanobarcodes. Template membranes for the deposition of materials are prepared using photolithographic techniques.
Disposable Optical Cuvette Cartridge With Low Fluorescence Material
A disposable cuvette cartridge for optical measurements is formed from three flexible thin layers. The middle layer is an adhesive sheet with cut out regions, typically between 30 and 50, serving as optical chambers bounded by the two outer layers. Inlet and vent holes in one of the outer sheets provide access to the optical chambers. At least one of the outer sheets is made of a material having low fluorescence, such as a cyclo-olefin copolymer. With its low background fluorescence, the cuvette cartridge is useful for high-throughput fluorescence measurements of biological samples.
Optical Architectures For Microvolume Laser-Scanning Cytometers
Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).