The present invention relates to tumor necrosis factor (TNF) antagonists and corresponding nucleic acids derived from tumor necrosis factor receptors (TNFRs) and their use in the treatment of inflammatory diseases. These proteins are soluble secreted decoy receptors that bind to TNF and prevent TNF from signaling to cells. In particular, the proteins are mammalian TNFRs that lack exon 7 and which can bind TNF and can act as a TNF antagonist.
Soluble Thf Receptors And Their Use In Treatment Of Disease
Peter L. Sazani - Chapel Hill NC, US Maria Graziewicz - Chapel Hill NC, US Ryszard Kole - Chapel Hill NC, US
International Classification:
A61K 31/7088 A61P 29/00 C12N 5/02 C07H 21/04
US Classification:
514 44 R, 536 241, 435375
Abstract:
The present invention relates to splice switching oligonucleotides or splice switching oligomers (SSOs). The preferred SSOs according to the invention target exon 7 of TNFR1 (TNFRSF1A) or TNFR2 (TNFRSF1A) pre-mRNA, typically resulting in the production of TNFR variants which comprise a deletion in part or the entire exon 7 respectfully. SSOs targeting exon 7 are found to result in a soluble form of the TNFR, which has thereputic benefit for treatment of inflammatory diseases. The SSO's are characterized in that they are substantially incapable or incapable of recruiting RNaseH.
Resumes
Associate Director, Global Project Management, Neuroscience
Syneos Health (Previously Inc Research/Inventiv Health)
Associate Director, Global Project Management, Neuroscience
Syneos Health Clinical Solutions (Previously Inc Research/Inventiv Health) Apr 2015 - Feb 2017
Senior Project Manager, Global Project Management, Neuroscience
Syneos Health Clinical Solutions (Previously Inc Research/Inventiv Health) May 2010 - Apr 2015
Project Manager, Global Project Management, Neuroscience
Inc Research Nov 2008 - Feb 2010
Global Clinical Developement Specialist
Sarepta Therapeutics Mar 2004 - Oct 2008
Senior Scientist, Discovery Research
Education:
Institute of Biochemistry and Biophysics
Doctorates, Doctor of Philosophy, Molecular Biology
University of Warsaw
University of Warsaw
Bachelors, Bachelor of Science, Biology
Skills:
Clinical Research Cro Ctms Clinical Monitoring Clinical Trials Clinical Development Lifesciences Edc Oncology Sop Diabetes Infectious Diseases Gcp Molecular Biology Pharmaceutical Industry Therapeutic Areas Drug Development Ich Gcp Clinical Data Management Biotechnology Biochemistry Clinical Operations Protocol
Interests:
Novel Drugs Sci Fi Books and Good Food Applicable Clinical Research Clinical Trial Recruitment Clinical Trial Logistics