Maria L Simonova

US Patent:

20020142297, Oct 3, 2002

Filed:

Dec 18, 2000

Appl. No.:

09/739068

Inventors:

Alexei Bogdanov - Arlington MA, US
Ralph Weissleder - Charlestown MA, US
Maria Simonova - Boston MA, US

Assignee:

The General Hospital Corporation, a Massachusetts corporation

International Classification:

C12Q001/68
G01N033/53
C07K014/435

US Classification:

435/006000, 435/007100, 530/400000

Abstract:

Described are short peptide sequences, termed recombinant peptide chelates (RPCs), and the imaging marker genes that encode them. The RPCs can be expressed in parallel with the expression of any other desired gene (e.g., a therapeutic gene), and used to easily confirm the expression of the therapeutic gene product. The RPCs are expressed in the cell or on the cell surface concurrently with the therapeutic gene product, and can be assayed by standard imaging techniques.