Mark P Carol

US Patent:

6393096, May 21, 2002

Filed:

May 27, 1999

Appl. No.:

09/320980

Inventors:

Mark P. Carol - Sewickley PA
Robert Hill - Sewickley PA
Bruce H. Curran - Sewickley PA
Richard Nash - Sewickley PA

Assignee:

Nomos Corporation - Sewickley PA

International Classification:

A61N 510

US Classification:

378 65, 378151

Abstract:

A method and apparatus for determining an optimized radiation beam arrangement for applying radiation to a tumor target volume while minimizing radiation of a structure volume in a patient, comprising: using a computer to computationally obtain a proposed radiation beam arrangement; using the computer to computationally change the proposed radiation beam arrangement iteratively, incorporating a cost function at each iteration to approach correspondence of a CDVH associated with the proposed radiation beam arrangement to a CDVH associated with a pre-determined desired dose prescription; comparing the dose distribution to a prescribed dose for the tumor volume and surrounding tissue structures, and increasing or decreasing radiation beam intensity if the change of the proposed beam arrangement leads to a greater correspondence to the desired dose prescription to obtain an optimized radiation beam arrangement.

US Patent:

6423077, Jul 23, 2002

Filed:

Jul 13, 2001

Appl. No.:

09/905833

Inventors:

Mark Carol - Sewickley PA
James L. Day - Cincinnati OH
Erik G. Miller - Pittsburgh PA
Robert J. Riker - Pittsburgh PA

Assignee:

Ohio Medical Instrument Company, Inc. - Cincinnati OH

International Classification:

A61B 603

US Classification:

606130, 600424

Abstract:

An apparatus and method are disclosed for displaying a path between a selected target and selected points on a patients skull and for guiding surgical instruments along any selected path. The system is comprised of an image display system, an articulated arm and probe, and a stereotactic system. The sub-systems are coupled to one another so that the articulated probe may be used to select patient fiducial points that correspond to selected image fiducial points. Using these points, the image display system coregisters the external locations to the displayed images so that the probe condition may be displayed with the displayed images. The system further permits the identification of a selected target within a patients brain and to project a path from the external position to the target prior to the performance of a craniotomy. After evaluation of the path, a surgeon may lock the stereotactic system in place to preserve a selected surgical path and to guide instruments along that path. A method of utilizing the system to perform such surgical procedures is also described.

US Patent:

8050384, Nov 1, 2011

Filed:

Oct 14, 2008

Appl. No.:

12/251298

Inventors:

Mark Philip Carol - Burlingame CA, US
Joseph A. Heanue - Oakland CA, US

Assignee:

Triple Ring Technologies, Inc. - Newark CA

International Classification:

A61N 5/10

US Classification:

378 65, 378 64

Abstract:

A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.

US Patent:

8409070, Apr 2, 2013

Filed:

Oct 26, 2007

Appl. No.:

11/978147

Inventors:

Mark P. Carol - Burlingame CA, US
James E. Jervis - Atherton CA, US
Paul A. Lovoi - Saratoga CA, US

Assignee:

Xoft, Inc. - Sunnyvale CA

International Classification:

A61N 5/00

US Classification:

600 3

Abstract:

Brachytherapy treatment of a patient's lung tissue following resection is effected using a balloon applicator which is inserted, normally through the same opening used for the surgery, through the chest wall and into the cavity. The lung and chest openings are closed around the applicator and generally sealed around the applicator. A suction port is provided, in a suction circuit of the applicator, to withdraw fluid from the pleural cavity, at intervals as needed, to assure that the lung can be inflated. Different embodiments of suction circuits are disclosed. A bronchial applicator and method are also disclosed.

US Patent:

8644452, Feb 4, 2014

Filed:

Oct 21, 2011

Appl. No.:

13/279208

Inventors:

Mark Philip Carol - Burlingame CA, US
Joseph Anthony Heanue - Oakland CA, US

Assignee:

Triple Ring Technologies, Inc. - Newark CA

International Classification:

A61N 5/10

US Classification:

378 65, 378145

Abstract:

A device is used to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other, in a predetermined parallel, planar, or similar geometry, each source equipped with blocking and attenuation mechanisms, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue. A plurality of overlapping beams indexed on a millimeter or submillimeter grid can converge on a target volume loaded with gold nanoparticles to deliver a tumorcidal dose of radiation in as little as a single session to tumor cells but not to normal cells or to deliver serial radiosurgical treatments.

US Patent:

20050276377, Dec 15, 2005

Filed:

Jun 9, 2005

Appl. No.:

11/149565

Inventors:

Mark Carol - San Francisco CA, US

International Classification:

A61N005/10

US Classification:

378065000

Abstract:

A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.

US Patent:

20130064344, Mar 14, 2013

Filed:

Aug 17, 2012

Appl. No.:

13/588009

Inventors:

Mark Carol - Burlingame CA, US

International Classification:

A61B 6/03

US Classification:

378 10

Abstract:

A CT scanning system for patients is provided comprising a nonrotating x-ray source and detector array bracketing a turntable on which stands or sits the patient that is being imaged. As the patient rotates between the x-ray source and the detector array that move along the vertical axis in tandem for each angular position of the patient, imaging data is collected of the patient from multiple angles at multiple levels that are reconstructed to form computed tomographic images that cover the entire region of interest.

US Patent:

20130066134, Mar 14, 2013

Filed:

Aug 4, 2012

Appl. No.:

13/567047

Inventors:

Mark Carol - Burlingame CA, US

International Classification:

A61B 6/04
A61N 5/10

US Classification:

600 1, 378 65, 378 62

Abstract:

A radiation system is provided comprising a single source of therapeutic radiation that is directed toward at least two treatment spaces in succession. Each treatment space houses a patient to be treated, each patient being secured generally by a separate supporting device adapted to support the patient in a generally sitting or standing or horizontal position. The x-ray source first delivers at least one beam to the first patient in the first space and then the x-ray source/patient relationship is adjusted so as to deliver an at least one beam to an at least second patient in a second space.