Matthew J Leader

US Patent:

59164255, Jun 29, 1999

Filed:

May 16, 1996

Appl. No.:

8/648675

Inventors:

Matthew J. Leader - Laguna Niguel CA
Jeffrey Graves - San Clemente CA

Assignee:

Sendx Medical, Inc. - Carlsbad CA

International Classification:

G01N 27333

US Classification:

204416

Abstract:

The present invention is an electronic wiring substrate for sensors formed over a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially negligible effect on the sensor. Only a small amount of conductive material which fills each through hole is in contact with each associated electrode. Therefore, the purity of the electrode is not significantly altered by the conductive material coupled to the electrode. A relatively large number of sensors can be formed on the surface of the substrate within a relatively small fluid flowcell. Thus, more information can be attained using less blood. The substrate is essentially impervious to aqueous electrolytes and blood over long periods of storage in potentially corrosive environments. Since the substrate does not break down or become unstable when exposed over time to such reactive environments, the isolation that is provided by the substrate remains very high between each sensor and each other sensor, between each sensor and each conduction path, and between each conduction path and each other conduction path.

US Patent:

61938645, Feb 27, 2001

Filed:

Nov 2, 1998

Appl. No.:

9/184471

Inventors:

Matthew J. Leader - Laguna Niguel CA
Douglas R. Savage - Del Mar CA

Assignee:

SenDx Medical, Inc. - Carlsbad CA

International Classification:

G01N 27333

US Classification:

204409

Abstract:

A blood analyzer sensor cartridge comprises a housing having chamber and a sensor assembly within the chamber, a first fluid port having an articulated inlet aspiration tube for direct introduction of a sample, a first fluid path in the housing communicating the first fluid port with the sensor assembly, a second fluid port in the housing adapted for connection to an analyzer, and a second fluid path in the housing communicating the sensor assembly with the second fluid port, the articulated tube is pivotally mounted to the housing for selective orientation within a range of up to ninety degrees, the tube is moveable from a protective recess in the housing to a position normal to a face of the housing.

US Patent:

58442006, Dec 1, 1998

Filed:

May 16, 1996

Appl. No.:

8/648694

Inventors:

Matthew J. Leader - Laguna Niguel CA
Jeffrey Graves - San Clemente CA
John M. Moorman - Carlsbad CA

Assignee:

SenDex Medical, Inc. - Carlsbad CA

International Classification:

B23K 2600

US Classification:

21912171

Abstract:

The present invention is a method for drilling a subminiature through hole through a substrate. The through holes of the present invention are preferably drilled through an alumina substrate which is essentially impervious to aqueous electrolytes and blood over long periods of storage in potentially reactive environments. The holes are drilled by directing a sealed type CO. sub. 2 laser at a predetermined position located on the substrate, energizing the laser at a power of approximately 75 to 225 watts, such that the laser beam focuses on the substrate at the predetermined position, and treating the substrate after the laser has drilled the hole.

US Patent:

49272225, May 22, 1990

Filed:

Jun 16, 1986

Appl. No.:

6/874927

Inventors:

Tadao Kamiya - Anaheim CA
Matthew J. Leader - Long Beach CA

Assignee:

Shiley Incorporated - Irvine CA

International Classification:

G02B 626

US Classification:

350 9615

Abstract:

A device for transmitting electromagnetic radiation to a radiation sensitive component and receiving output radiation from said component comprising a radiation-transmissible junction formed by contacting the tip of a first optical fiber with an intermediate portion of a second optical fiber, said junction being encased in an opaque, radiation reflective jacket. A method for determining a desired parameter using such device is also disclosed.

US Patent:

60224630, Feb 8, 2000

Filed:

May 16, 1996

Appl. No.:

8/649009

Inventors:

Matthew J. Leader - Laguna Niguel CA
Jeffrey Graves - San Clemente CA

Assignee:

SenDx Medical, Inc. - Carlsbad CA

International Classification:

G01N 27333
G01N 27404

US Classification:

204416

Abstract:

The present invention is a sensor having an electrode formed in electrical contact with a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially negligible effect on the sensor. A relatively large number of sensors can be formed on the surface of the substrate within a relatively small fluid flowcell. Thus, more information can be attained using less analyte. The sensors of the present invention are preferably disposed on an alumina substrate which is essentially impervious to aqueous electrolytes and blood over long periods of storage in potentially corrosive environments. Since the substrate on which the sensors are deposited, and the encapsulants which insulate the conductive elements of the sensor do not break down or become unstable when exposed over time to such corrosive environments, the isolation that is provided remains very high between each sensor and each other sensor, between each sensor and each conduction path, and between each conduction path and each other conduction path. The superior isolation provides for a high level of accuracy in the sensor of the present invention.

US Patent:

48330914, May 23, 1989

Filed:

Feb 6, 1987

Appl. No.:

7/012105

Inventors:

Matthew J. Leader - Long Beach CA
Tadao Kamiya - Anaheim CA

Assignee:

Shiley Incorporated - Irvine CA

International Classification:

G01N 3300

US Classification:

436133

Abstract:

A method of measuring the concentration of carbon dioxide in a medium by determining the water content in a pH-independent sensor system comprising an optical fiber having attached thereto a fluorescence indicator embedded in a carrier matrix containing a miscible mixture of water and non-aqueous solvent in predetermined proportions and being separated from said medium by a gas-permeable, water-impermeable diffusion membrane, said indicator, when excited by excitation radiation of a predetermined wavelength, emitting fluorescent emission whose intensity is dependent upon the ratio of water to non-aqueous solvent present in the system such that the ratio of intensities of emitted radiation is therefore proportional to the amount of water present and diffusion of carbon dioxide through said gas-permeable membrane and subsequent reaction with water to deplete the water content of the system induces a change in the intensities of said emissions, which method comprises transmitting excitation radiation through said optical fiber and measuring the ratio of the intensities of the emitted radiation, thereby obtaining a determination of the water content and calculating therefrom the carbon dioxide concentration in the surrounding medium.

US Patent:

53384350, Aug 16, 1994

Filed:

Jun 26, 1992

Appl. No.:

7/905255

Inventors:

Ronald E. Betts - La Jolla CA
Douglas R. Savage - Del Mar CA
Richard J. Koerner - San Diego CA
Matthew J. Leader - Laguna Niguel CA
Kee V. Sin - Lino Lakes MN
Jeffrey A. Graves - San Juan Capistrano CA
Marshall L. Sherman - Cardiff CA

Assignee:

PPG Industries, Inc. - Pittsburgh PA

International Classification:

G01N 2726

US Classification:

204406

Abstract:

A plastic covered nonconducting substrate with an electrical circuit means is secured to the extent to withstand the presence of liquids in contact with the substrate. The covered substrate can have the substrate with one or more fluid preconditionable electrical components, a housing secured to the substrate to maintain contact of the preconditioning fluid with the electrical component like a sensor, and moisture impervious seals to cover openings in the housing for the disposition of the preconditioning fluid in the housing for contact with the electrical component on the substrate. The housing can have one or more parts and have one or more channels for containing the preconditioning fluid. The electrical component can be an improved electronic wiring board having a thermistor and at least one blood gas sensor supported, in close relation, one to the other, on one side of the board and a heater supported on the other side of the board to provide heat in response to temperature sensed by the thermistor, to at least the region where the thermistor and the blood gas sensor are positioned on the board to control the temperature of the region of the board within a narrow distribution of temperatures.

US Patent:

54219817, Jun 6, 1995

Filed:

Nov 5, 1993

Appl. No.:

8/147411

Inventors:

Matthew J. Leader - Laguna Niguel CA
Kee V. Sin - White Bear Lake MN

Assignee:

PPG Industries, Inc. - Pittsburgh PA

International Classification:

G01N 2726

US Classification:

204409

Abstract:

A sensor apparatus is provided that is the sensor with or without accompanying sample collector means and calibration means in a hermetically sealed layer that contains at least one preconditioning fluid. The preconditioning fluid is an activating fluid when the sensor is in an unsealed housing and can be either or both the activating fluid or a controlled-content fluid when the sensor is in a sealed housing. The sealed housing is one that has the preconditioning fluid sealed in fluid contact with the one or more sensors on a sensor element. The sensor element also has an electrical circuit means in electrical contact with the one or more sensor on a nonconducting substrate. When both preconditioning fluids are present the activating fluid is in fluid contact with the one or more sensors in the sealed housing and the known-content fluid is present in the atmosphere in the hermetically sealed layer outside the sealed housing. The sealed layer is impervious to gas and moisture and is a diffusion-tight boundary or barrier.