Matti S Hamalainen

Author:

Matti Hamalainen

ISBN #:

0470869178

US Patent:

20090254146, Oct 8, 2009

Filed:

Apr 3, 2009

Appl. No.:

12/418324

Inventors:

Giorgio Bonmassar - Lexington MA, US
Matti S. Hamalainen - Boston MA, US
Bruce Rosen - Lexington MA, US

International Classification:

A61N 1/36

US Classification:

607 45

Abstract:

An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.

US Patent:

20170332933, Nov 23, 2017

Filed:

Nov 9, 2015

Appl. No.:

15/521987

Inventors:

- Boston MA, US
- BOSTON MA, US
Matti Hamalainen - Boston MA, US
Behtash Babadi - Allston MA, US

International Classification:

A61B 5/0436
A61B 5/0476
A61B 5/055
A61B 5/00

Abstract:

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the method employs a subspace-pursuit algorithm rooted in compressive sampling theory, performs a hierarchical search for sparse subcortical and cortical sources underlying the measurement, and estimates millisecond-scale currents in these sources to explain the data. The method can be used to recover thalamic and brainstem contributions to non-invasive M/EEG data, and to enable non-invasive study of fast timescale dynamical and network phenomena involving widespread regions across the human brain.