Dariush Davalian - San Jose CA Maureen H. Beresini - Moss Beach CA Svetlana Alexander - Sunnyvale CA Mae Wan-Leng Hu - Los Altos CA Edwin F. Ullman - Atherton CA
A method of measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is disclosed. A method of inactivating interfering cross-reactive material in an assay for measuring the amount of cyclosporin in a sample suspected of containing cyclosporin is also disclosed. Compositions wherein cyclosporin is conjugated to an immunogenic carrier or a label, optionally through a linking group, at an alanine nitrogen atom of the cyclic backbone of cyclosporin are also disclosed. Compositions wherein atiocyclosporin is conjugated, optionally through a linking group, to an immunogenic carrier or a label are also disclosed. Where cyclosporin is conjugated to an immunogenic carrier, the conjugates may be used as immunogens for the preparation of antibodies which are capable of recognizing cyclosporin. Where atiocyclosporin is conjugated to an immunogenic carrier, the conjugates may be used as immunogens for the preparation of antibodies which are capable of recognizing interfering cross-reactive material but substantially incapable of recognizing cyclosporin or cyclosporin-label conjugates. Where cyclosporin is conjugated to a label, the conjugates may be used as part of a signal producing system in cyclosporin assays.
Secreted And Transmembrane Polypeptides And Nucleic Acids Encoding The Same
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 16/00 C07K 16/40
US Classification:
5303879, 5303881, 53038815, 5303891, 5303913
Abstract:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Kevin P. Baker - Damestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 14/525 C07H 21/04
US Classification:
530351, 424 852, 536 235, 435 6952
Abstract:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 38/00 A61K 38/17 C07K 14/00
US Classification:
530350, 514 12, 5303873
Abstract:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Secreted And Transmembrane Polypeptides And Nucleic Acids Encoding The Same
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 14/435
US Classification:
530350
Abstract:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Secreted And Transmembrane Polypeptides And Nucleic Acids Encoding The Same
Kevin P. Baker - Darnestown MD, US Maureen Beresini - Moss Beach CA, US Laura DeForge - Pacifica CA, US Luc Desnoyers - San Francisco CA, US Ellen Filvaroff - San Francisco CA, US Wei-Qiang Gao - Palo Alto CA, US Mary E. Gerritsen - San Mateo CA, US Audrey Goddard - San Francisco CA, US Paul J. Godowski - Hillsborough CA, US Austin L. Gurney - Belmont CA, US Steven Sherwood - Los Altos CA, US Victoria Smith - Burlingame CA, US Timothy A. Stewart - San Francisco CA, US Daniel Tumas - Orinda CA, US Colin K. Watanabe - Moraga CA, US William I. Wood - Hillsborough CA, US Zemin Zhang - Foster City CA, US
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.