Meier E Freed from Paoli, PA

1,3-Bridged Amino Tetralins
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US Patent:

40340414, Jul 5, 1977
Filed:

Mar 13, 1975
Appl. No.:

5/558021
Inventors:

Meier E. Freed - Paoli PA
John R. Potoski - Spring City PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07C 8764
US Classification:

260571
Abstract:

1,3-Bridged-2-amino tetralins, having spiro substitution or the bridge, and intermediates thereto. The final products have analgesic activity.

Antiarrhythmic Cyclooct[B]Indoles
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US Patent:

45461937, Oct 8, 1985
Filed:

Dec 20, 1984
Appl. No.:

6/684211
Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Meier E. Freed - Paoli PA
Thomas J. Colatsky - Paoli PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07D20970
US Classification:

548448
Abstract:

This invention provides a group of antiarrhythmic agents of the formula: ##STR1## in which R. sub. 1 is --CO. sub. 2 H, --CO. sub. 2 (CH. sub. 2). sub. n --NR. sub. 4 R. sub. 5, --CONR. sub. 6 R. sub. 7, --NHCO. sub. 2 R. sub. 8 or --NHCO. sub. 2 (CH. sub. 2). sub. o --NR. sub. 9 R. sub. 10 where R. sub. 4 and R. sub. 5 are H or alkyl of 1 to 6 carbon atoms and n is 1 to 6; R. sub. 6 and R. sub. 7 are H or alkyl of 1 to 6 carbon atoms; R. sub. 8 is alkyl of 1 to 6 carbon atoms; and R. sub. 9 and R. sub. 10 are alkyl of 2 to 6 carbon atoms and o is 1 to 6; R. sub. 2 and R. sub. 3 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms; and m is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, and a method for their use.

Benzocycloalkane Amines
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US Patent:

45408068, Sep 10, 1985
Filed:

Dec 22, 1983
Appl. No.:

6/564588
Inventors:

Meier E. Freed - Paoli PA
Magid A. Abou-Gharbia - Wilmington DE
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07C 8702
C07C10172
C07C103127
A61K 3122
US Classification:

560139
Abstract:

Benzocycloalkane amine derivatives and their non-toxic acid addition salts as novel analgesic agents.

Benzobicycloalkane
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US Patent:

40013316, Jan 4, 1977
Filed:

Dec 3, 1973
Appl. No.:

5/421375
Inventors:

Meier E. Freed - Paoli PA
John R. Potoski - Spring City PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07C 4102
US Classification:

260571
Abstract:

Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and anti-inflammatory activity.

3-[Pyridinylalkyl And Piperidinylalkyl]-2,3,4,4A-Tetrahydro-1H-Pyrazino[1,2-A]Quinoxalin-5(6H) -Ones
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US Patent:

42039878, May 20, 1980
Filed:

May 21, 1979
Appl. No.:

6/040609
Inventors:

Meier E. Freed - Paoli PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

A61K 31495
C07D48704
US Classification:

424250
Abstract:

Disclosed herein are compounds of the formula: ##STR1## wherein n is an integer from 1 to 8; R is hydrogen or lower alkyl; Y is hydrogen, lower alkyl, lower alkoxy, chlorine, fluorine, or trifluoromethyl in the 7, 8, or 9 position; A is hydrogen, lower alkyl, phen(lower)alkyl, or diphenyl(lower)alkyl; and the pyridinyl or piperidinyl moiety is joined to the alkylene bridging group at the 2 or 4 position; or non-toxic acid addition salts thereof. These compounds exhibit hypotensive effects in hypertensive animals and also exhibit anti-secretory properties.

Benzobicycloalkane Amine N-Oxides And The Salts Thereof
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US Patent:

39578720, May 18, 1976
Filed:

Feb 26, 1975
Appl. No.:

5/553418
Inventors:

Meier E. Freed - Paoli PA
John R. Potoski - Spring City PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07C 9140
US Classification:

260571
Abstract:

Benzobicycloalkane amines, their pharmacologically acceptable addition salts, intermediates therefore the processes for their preparation and use. The compounds of the invention exert analgesic and antiinflammatory activity.

2,3,4,9-Tetrahydro-2-Heteroarylalkyl-1H-Pyrido(3,4-B)Indoles Having Antihypertensive Properties
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US Patent:

47192119, Jan 12, 1988
Filed:

Mar 7, 1986
Appl. No.:

6/837612
Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Meier E. Freed - Bryn Mawr PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

A61K 31495
C07D47106
US Classification:

514253
Abstract:

This invention concerns tetrahydropyridoindoles of the formula: ##STR1## wherein Q represents ##STR2## in which R. sub. 3 is hydrogen, C. sub. 1-4 alkyl, C. sub. 1-4 alkoxy, or --COO(C. sub. 1-2) alkyl, and n is an integer from 1 to 7; R. sub. 1 is hydrogen, halogen, hydroxy, or C. sub. 1-3 alkyl; and R. sub. 2 is hydrogen, C. sub. 1-4 alkyl or --(CH. sub. 2). sub. m --A where A is --N(CH. sub. 3). sub. 2,--N(C. sub. 2 H. sub. 5). sub. 2, ##STR3## in which Ar is 2-pyrimidinyl, 2-pyrazinyl, phenyl, or phenyl substituted by a methyl, ethyl, methoxy, ethoxy, or trifluoromethyl group; and m is an integer from 1-4, or physiologically acceptable salts thereof, providing however that when n is 1, Q may not be quinolinyl. These compounds exhibit antihypertensive properties. Four of the disclosed compounds also exhibit antipsychotic properties.

4-Substituted-Piperidino Carboxamides
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US Patent:

44143893, Nov 8, 1983
Filed:

May 25, 1982
Appl. No.:

6/381673
Inventors:

Meier E. Freed - Paoli PA
Assignee:

American Home Products Corporation - New York NY
International Classification:

C07D48704
A61K 31495
US Classification:

544349
Abstract:

The compounds ##STR1## where R is hydrogen, alkyl, phenyl or substituted phenyl and R. sup. 1 is 2-furanyl, 2-benzofuranyl, 2-thienyl or 2-pyridyl or pharmaceutically acceptable salts thereof are antihypertensive, antisecretory agents.

Meier E Freed