Michael J Amery

US Patent:

6613325, Sep 2, 2003

Filed:

Jun 1, 2000

Appl. No.:

09/585030

Inventors:

Michael J. Amery - Washington Crossing PA
Paul Sibbons - Harrow, GB
Stuart Burnett - Liverpool, GB
Sally-Anne Rickets - Amersham, GB
Peter A. D. Edwardson - Leeds, GB
Jonathan Hughes - Buckinghamshire, GB
Derek A. Hollingsbee - Neston, GB
Stewart A. Cederholm-Williams - Oxford, GB
Horace R. Trumbull - Skillman NJ
Herman Eugene Griffin - Wakefield RI

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 3848

US Classification:

424 9464, 424 7806, 424 77, 424423, 424422

Abstract:

In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i. e. , has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patients own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e. g. , thrombin, etc.

US Patent:

59615028, Oct 5, 1999

Filed:

Mar 3, 1997

Appl. No.:

8/810098

Inventors:

Michael J. Amery - Washington Crossing PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61F 544

US Classification:

604332

Abstract:

The waste collection pouch has a wall adapted to be situated adjacent the body and a stoma receiving inlet. A collar may be affixed to the wall around the inlet and coated with an adhesive layer. An adhesive layer is provided directly on the pouch wall, either covering the entire surface of the wall or a section along the periphery, so as to affix the pouch wall directly to the body. The pouch may have an oval shape with its major axis adapted to extend laterally or may be circular. The bottom edge may be linear or include an inwardly indented section.