Michael R Jirousek

US Patent:

7829556, Nov 9, 2010

Filed:

Jun 20, 2008

Appl. No.:

12/214804

Inventors:

Jean Bemis - Arlington MA, US
Jeremy S. Disch - Natick MA, US
Michael Jirousek - Cambridge MA, US
Walter Joseph Lunsmann - Harvard MA, US
Pui Yee Ng - Boston MA, US
Chi B. Vu - Arlington MA, US

Assignee:

Sirtris Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/535
C07D 413/00

US Classification:

5142332, 544124

Abstract:

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

US Patent:

8173831, May 8, 2012

Filed:

Jul 8, 2009

Appl. No.:

12/499779

Inventors:

Jill C. Milne - Brookline MA, US
Michael R. Jirousek - Cambridge MA, US
Jean E. Bemis - Arlington MA, US
Jesse J. Smith - Waltham MA, US

Assignee:

Catabasis Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07C 269/00
A61K 31/20

US Classification:

560115, 560146, 514166, 514548, 514559

Abstract:

The invention relates to Fatty Acid Acetylated Salicylate Derivatives; compositions comprising an effective amount of a Fatty Acid Acetylated Salicylate Derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a Fatty Acid Acetylated Salicylate Derivative.

US Patent:

8247565, Aug 21, 2012

Filed:

Sep 27, 2010

Appl. No.:

12/891667

Inventors:

Jean Bemis - Arlington MA, US
Jeremy S. Disch - Natick MA, US
Michael Jirousek - Cambridge MA, US
Walter Joseph Lunsmann - Harvard MA, US
Pui Yee Ng - Boston MA, US
Chi B. Vu - Arlington MA, US

Assignee:

Sirtris Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 417/00
A61K 31/44

US Classification:

5462701, 514338

Abstract:

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

US Patent:

8304551, Nov 6, 2012

Filed:

Aug 31, 2010

Appl. No.:

12/872555

Inventors:

Jill C. Milne - Brookline MA, US
Michael R. Jirousek - Cambridge MA, US
Jean E. Bemis - Arlington MA, US
Chi B. Vu - Arlington MA, US

Assignee:

Catabasis Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 211/72
A61K 31/44

US Classification:

546316, 514355

Abstract:

The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.

US Patent:

8304552, Nov 6, 2012

Filed:

Mar 22, 2012

Appl. No.:

13/427001

Inventors:

Jill C. Milne - Brookline MA, US
Michael R. Jirousek - Cambridge MA, US
Jean E. Bemis - Arlington MA, US
Chi B. Vu - Arlington MA, US

Assignee:

Catabasis Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D 211/72
A61K 31/44

US Classification:

546316, 514355

Abstract:

The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.

US Patent:

20100184730, Jul 22, 2010

Filed:

Feb 26, 2010

Appl. No.:

12/714308

Inventors:

Chi B. Vu - Arlington MA, US
Jean E. Bemis - Arlington MA, US
Michael R. Jirousek - Cambridge MA, US
Jill C. Milne - Brookline MA, US
Jesse J. Smith - Waltham MA, US

International Classification:

A61K 31/609
C07C 69/587
A61K 31/616
C07C 229/64
C07D 241/04
A61K 31/196
C07C 233/78
C07C 323/42
C07D 207/416
A61P 3/10
A61P 9/06
A61P 9/10
A61P 3/06
A61P 13/12
A61P 25/28
A61P 1/00
A61P 25/16
A61P 21/00

US Classification:

514166, 554224, 514159, 554110, 544387, 514576, 554106, 554102, 548544

Abstract:

The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylated salicylate derivative.

US Patent:

20100215632, Aug 26, 2010

Filed:

Mar 19, 2008

Appl. No.:

12/450252

Inventors:

Olivier Boss - Boston MA, US
Siva Worcester - Worcester MA, US
Andre Iffland - Cambridge MA, US
Jesse Smith - Waltham MA, US
Jill Milne - Brookline MA, US
Michael Jirousek - Cambridge MA, US

Assignee:

Sirtris Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 38/43
C12Q 1/44
C12Q 1/68
C12Q 1/02

US Classification:

424 941, 435 19, 435 6, 435 29

Abstract:

Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

US Patent:

20110082120, Apr 7, 2011

Filed:

Oct 5, 2010

Appl. No.:

12/898453

Inventors:

Jill C. Milne - Brookline MA, US
Michael R. Jirousek - Cambridge MA, US
Jean E. Bemis - Arlington MA, US
Chi B. Vu - Arlington MA, US

International Classification:

A61K 31/609
C07C 233/81
C07C 57/42
A61P 3/00
A61P 9/00
A61P 29/00

US Classification:

514166, 564154, 562431, 514159

Abstract:

The invention relates to substituted thioacetic acid salicylate derivatives; compositions comprising an effective amount of a substituted thioacetic acid salicylate derivative; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a substituted thioacetic acid salicylate derivative.