Michael J Szymonifka from 65 Whittier Rd, Clark, NJ 07066, age 69, Phone: 7323815351

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Work:

Coldwell Banker Westfield West
Clark, NJ

Tryptamine Sulfonamides As 5-Htantagonists
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US Patent:

8138219, Mar 20, 2012
Filed:

Nov 25, 2008
Appl. No.:

12/739984
Inventors:

Alexander Pasternak - Princeton NJ, US
Michael J. Szymonifka - Clark NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

A61K 31/404
C07D 209/14
US Classification:

514415, 548506
Abstract:

Novel compounds of the structural formula (I) are antagonists of the 5-HTreceptor and are useful in the treatment, prevention and suppression of diseases mediated by the 5-HTreceptor. The compounds of the present invention are useful in the treatment of obesity, diabetes, metabolic disorder, cognitive disorders, age related cognitive disorder, depression, mania, bipolar disorders, schizophrenia, anxiety, generalized anxiety disorder, panic disorder, and obsessive compulsive disorder, epilepsy, convulsions, migraine, substance withdrawal from substances including but not limited to opiates, nicotine, tobacco products, alcohol, benzodiazepines, sedatives, and the like, sleep disorders, attention deficit/hyperactivity disorder, and Alzheimer's disease.

Niacin Receptor Agonists, Compositions Containing Such Compounds And Methods Of Treatment
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US Patent:

20090258862, Oct 15, 2009
Filed:

Aug 25, 2006
Appl. No.:

11/991188
Inventors:

Steven L. Colletti - Princeton Junction NJ, US
Hong Shen - West Windsor NJ, US
James R. Tata - Westfield NJ, US
Michael J. Szymonifka - Clark NJ, US
International Classification:

A61K 31/55
C07D 403/04
C07D 487/08
C07D 401/04
A61K 31/495
US Classification:

51421705, 544353, 544344, 540599, 544363, 514249
Abstract:

Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.

Homoerythromycin A Derivatives Modified At The 4"-And 8A-Positions
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US Patent:

59858443, Nov 16, 1999
Filed:

Mar 26, 1992
Appl. No.:

7/855242
Inventors:

James V. Heck - Scotch Plains NJ
William J. Leanza - Berkeley Heights NJ
Ronald W. Ratcliffe - Matawan NJ
Thomas N. Salzmann - North Plainfield NJ
Kothandaraman Shankaran - Edison NJ
Michael J. Szymonifka - Clark NJ
Robert R. Wilkening - Maplewood NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07H 1708
US Classification:

514 29
Abstract:

Compounds of the formula: ##STR1## where R is hydrogen, hydroxyl, alkyl or acyl, R' and R" together are oxo, hydroxyimino or alkoxyimino, and R' and R" independently are hydrogen, hydroxyl, acyloxy, or amino substituted by any of hydrogen, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkoxycarbonyl, aralkoxycarbonyl, alkylsulfonyl or arylsulfonyl, and n is 0 or 1, and the pharmaceutically acceptable salts thereof. The compounds are macrolide antibiotics and are also useful as intermediates to the synthesis of other macrolide antibiotics. Pharmaceutical compositions and methods of their use are also provided for.

6-(1-Hydroxyethyl)Cyclonocardicin
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US Patent:

43748481, Feb 22, 1983
Filed:

Sep 14, 1981
Appl. No.:

6/301544
Inventors:

Burton G. Christensen - Cliffside Park NJ
James V. Heck - Fanwood NJ
Michael J. Szymonifka - Rahway NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3140
C07D48714
US Classification:

424274
Abstract:

Disclosed are 6-(1-hydroxyethyl)cyclonocardicins (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics. ##STR1## Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

Michael J Szymonifka