Michele A Benish from The Woodlands, TX, age 59

Thienopyrimidine-Based Inhibitors Of The Src Family
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US Patent:

RE39267, Sep 5, 2006
Filed:

Jun 28, 2004
Appl. No.:

10/878140
Inventors:

Michele A. Benish - Pearland TX, US
Michael Lawless - St. Charles MO, US
Raymond J. A. Budde - Bellaire TX, US
Assignee:

Board of Regents, The University of Texas System - Austin TX
International Classification:

C07D 495/04
A61K 31/519
A61P 19/10
A61P 31/12
US Classification:

5142601, 544278
Abstract:

Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Thienopyrimidine-Based Inhibitors Of The Src Family
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US Patent:

7285556, Oct 23, 2007
Filed:

Oct 23, 2001
Appl. No.:

10/399816
Inventors:

Michele A. Benish - Pearland TX, US
Michael Lawless - St. Charles MO, US
Raymond J. Budde - Bellaire TX, US
Assignee:

Board of Regents, The University of Texas Systems - Austin TX
International Classification:

A61K 31/519
C07D 495/04
US Classification:

5142601, 544278
Abstract:

Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. Compounds of the present invention, capable of such selective inhibition, are of the basic structure seen in formulae (I), (II) or (III):These compounds are useful in the treatment of a wide variety of diseases including hyperproliferative diseases, hematologic allergic/immunological diseases, or viral infections. Methods of synthesis of these compounds and their methods of inhibiting the Src family of tyrosine kinases are presented.

Thienopyrimidine-Based Inhibitors Of The Src Family
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US Patent:

6503914, Jan 7, 2003
Filed:

Oct 23, 2000
Appl. No.:

09/694145
Inventors:

Michele A. Benish - Pearland TX
Michael Lawless - St. Charles MO
Raymond J. A. Budde - Bellaire TX
Assignee:

Board of Regents, The University of Texas System - Austin TX
International Classification:

C07D49504
US Classification:

5142601, 544278
Abstract:

Various thienopyrimidine-based analog compounds that selectively inhibit the Src family of tyrosine kinases. These compounds are thienopyrimidines and contain a hydrozone bridge created by heating a thienopyrimidine hydrazine with an aldehyde in ethanol at reflux. Such compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Propionic Acid Derivatives And Methods Of Use Thereof
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US Patent:

20190225602, Jul 25, 2019
Filed:

Apr 1, 2019
Appl. No.:

16/372189
Inventors:

Ronald J. Biediger - Houston TX, US
Michele A. Benish - The Woodlands TX, US
Robert V. Market - Pearland TX, US
Michael M. Savage - Pearland TX, US
Brandon M. Young - Germantown TN, US
Assignee:

Aviara Pharmaceuticals, Inc. - Houston TX
International Classification:

C07D 417/12
C07D 213/75
C07D 409/12
Abstract:

Provided herein are methods for antagonizing the action of an α4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula Iwhere R, R, R, R, R, X and Rare as described herein.

Propionic Acid Derivatives And Methods Of Use Thereof
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US Patent:

20180312498, Nov 1, 2018
Filed:

Apr 26, 2017
Appl. No.:

15/497416
Inventors:

Ronald J. Biediger - Houston TX, US
Michele A. Benish - The Woodlands TX, US
Robert V. Market - Pearland TX, US
Michael M. Savage - Pearland TX, US
Brandon M. Young - Germantown TN, US
Assignee:

Aviara Pharmaceuticals, Inc. - Houston TX
International Classification:

C07D 417/12
C07D 213/75
Abstract:

Provided herein are compounds and pharmaceutical compositions of formula Iwhere R, R, R, R, R, X and Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an α4-integrin to treat various pathophysiological conditions.

Propionic Acid Derivatives And Methods Of Use Thereof
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US Patent:

20180312523, Nov 1, 2018
Filed:

Apr 26, 2017
Appl. No.:

15/497414
Inventors:

Ronald J. Biediger - Houston TX, US
Michele A. Benish - The Woodlands TX, US
Lindsay Bonner Hardy - Lexington MA, US
Vincent A. Boyd - Tyler TX, US
Robert V. Market - Pearland TX, US
Thomas P. Thrash - Houston TX, US
Brandon M. Young - Germantown TN, US
Assignee:

Aviara Pharmaceuticals, Inc. - Houston TX
International Classification:

C07D 498/04
C07D 213/75
C07D 213/64
C07D 207/327
C07C 69/618
C07D 307/54
C07D 401/12
C07D 221/18
C07D 207/333
C07C 313/06
C07D 333/22
C07D 231/16
C07D 471/04
C07D 261/08
C07D 213/55
C07D 213/48
C07D 213/69
C07C 47/575
C07C 47/55
C07D 209/08
C07D 237/14
Abstract:

Provided herein are compounds and pharmaceutical compositions of formula Iwhere R, R, R, R, Rand Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Michele A Benish