Nathan C Gianneschi

US Patent:

20080213916, Sep 4, 2008

Filed:

Aug 18, 2005

Appl. No.:

11/658606

Inventors:

Chad A. Mirkin - Wilmette IL, US
Nathan C. Gianneschi - San Diego CA, US
Jungseok Heo - Glenview IL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

G01N 33/53
C07F 9/28
C07F 19/00

US Classification:

436501, 568 10, 556 19, 534 15

Abstract:

Coordination complexes having at least two structural conformations are disclosed. The coordination complexes contain at least one metal center and at least one hemi-labile ligand, and change structural conformations due to the presence or absence of allosteric effectors. Methods of detecting an analyte using the coordination complexes are also disclosed.

US Patent:

20120149843, Jun 14, 2012

Filed:

Feb 1, 2012

Appl. No.:

13/363645

Inventors:

Nathan C. Gianneschi - San Diego CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C08F 291/12
A61K 9/70
C12Q 1/68
C08F 299/00
B05D 7/14
A61K 8/02
C12P 19/34
B82Y 40/00
B82Y 5/00

US Classification:

525 541, 424401, 424443, 435 61, 435 911, 525 542, 427216, 977788, 977915, 977890, 977906

Abstract:

The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.

US Patent:

20220389414, Dec 8, 2022

Filed:

Oct 28, 2020

Appl. No.:

17/772169

Inventors:

- Toronto, CA
- Madison WI, US
- Glasgow, GB
- Cambridge MA, US
- Evanston IL, US
Leroy CRONIN - Glasgow, GB
Abhishek SHARMA - Glasgow, GB
Yudong CAO - Cambridge MA, US
Nathan C. GIANNESCHI - Wilmette IL, US
Christopher James FORMAN - Chicago IL, US

International Classification:

C12N 15/10
G06N 99/00
G06N 10/60

Abstract:

Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem.

US Patent:

20220332670, Oct 20, 2022

Filed:

Jun 26, 2020

Appl. No.:

17/621908

Inventors:

- Evanston IL, US
Zhao WANG - Evanston IL, US
Naneki C. McCALLUM - Evanston IL, US
Nathan C. GIANNESCHI - Evanston IL, US
Zofia E. SIWICKA - Evanston IL, US

Assignee:

Northwestern University - Evanston IL

International Classification:

C07C 33/26
C07C 29/76
B29B 9/00
C08G 65/44
B82Y 5/00

Abstract:

In an aspect, a plurality of artificial melanin nanoparticles are provided, wherein: each melanin nanoparticle of the plurality of artificial melanin nanoparticles comprises a plurality of melanin oligomers; each melanin oligomer comprises a plurality of covalently-bonded melanin base units; and each melanin base unit comprises substituted or unsubstituted naphthalene. In an aspect, porous artificial melanin materials and methods of synthesizing porous artificial melanin materials are provided.

US Patent:

20220273607, Sep 1, 2022

Filed:

Jul 8, 2020

Appl. No.:

17/625023

Inventors:

- Evanston IL, US
Nathan C. GIANNESCHI - Evanston IL, US

Assignee:

NORTHWESTERN UNIVERSITY - Evanston IL

International Classification:

A61K 31/337
A61K 47/54
A61K 47/42
A61K 45/06
A61K 39/395
A61P 35/00

Abstract:

The present disclosure provides methods of using prodrugs of small-molecule cytotoxins for the treatment of cancer. In some embodiments, the cancer is a tumor comprising cells that overexpress fatty acid uptake proteins, such as cells that overexpress fatty acid translocase CD36. In some other aspects, the disclosure provides compositions suitable for use in such methods. In some further aspects, the disclosure provides combination therapies that may be suitable used in combination with the use of small-molecule prodrugs disclosed herein.

US Patent:

20230127548, Apr 27, 2023

Filed:

Sep 28, 2022

Appl. No.:

17/936216

Inventors:

- La Jolla CA, US
Eric Van Nostrand - La Jolla CA, US
Nathan Gianneschi - La Jolla CA, US
David A. Nelles - La Jolla CA, US
Sarah Barnhill - La Jolla CA, US
Anthony Rush - La Jolla CA, US

International Classification:

C12N 15/10

Abstract:

Provided herein are methods of identifying a cell uptake modulator of a molecule that include (a) contacting a plurality of cells of a cell-containing biological sample with a plurality of gene-editing agents, wherein a gene-editing agent from the plurality of gene-editing agents recognizes and alters a target gene of at least one cell of the plurality of cells; (b) contacting the plurality of cells with a plurality of molecules, wherein at least one molecule of the plurality of molecules is transported into at least one cell of the plurality of cells; and (c) detecting a presence of the at least one molecule in the plurality of cells, thereby identifying the cell uptake modulator of the molecule.

US Patent:

20230080523, Mar 16, 2023

Filed:

Sep 13, 2022

Appl. No.:

17/943667

Inventors:

Ali DHINOJWALA - Akron OH, US
Ming XIAO - Cambridge MA, US
Ziying HU - Wilmette IL, US
Matthew SHAWKEY - Ghent, BE
Nathan GIANNESCHI - Wilmette IL, US

Assignee:

THE UNIVERSITY OF AKRON - Akron OH

International Classification:

B01J 13/18
C09B 67/08
C09B 69/10

Abstract:

In various embodiments, the present invention is directed to a facile one-pot reverse emulsion process to assemble core-shell nanoparticles (CS-SMNPs) into bright and noniridescent photonic supraballs. In one or more embodiments, the present invention is directed to core-shell nanoparticles having an inner high refractive index (RI) core and an outer low RI shell. In one or more embodiment, the present invention includes core-shell nanoparticles using high RI (1.74) melanin cores and low-RI (1.45) silica shells. In various embodiments, these nanoparticles may be self-assembled into bright and noniridescent supraballs using a scalable one-pot reverse emulsion process. According to various embodiments of the present invention, it is possible to generate a full spectrum of structural colors with the combination of only two ingredients, synthetic melanin and silica.

US Patent:

20210301078, Sep 30, 2021

Filed:

Feb 10, 2021

Appl. No.:

17/172793

Inventors:

- Oakland CA, US
Nathan GIANNESCHI - San Diego CA, US
Carrie JAMES - San Diego CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C08G 61/02
C07H 21/00
C07K 14/00

Abstract:

Provided herein are compositions and methods of making high density nucleic acid polymers.