Nenad Z Svrzikapa

US Patent:

20220195429, Jun 23, 2022

Filed:

Jul 14, 2021

Appl. No.:

17/375658

Inventors:

- Singapore, SG
Meena - Belmont MA, US
Nenad Svrzikapa - Cambridge MA, US
Susovan Mohapatra - Belmont MA, US
Christopher J. Francis - Carlisle MA, US
Gregory L. Verdine - Boston MA, US
Anna Sokolovska - Somerville MA, US

International Classification:

C12N 15/113
C12N 15/115
A61P 25/28

Abstract:

Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

US Patent:

20210130821, May 6, 2021

Filed:

Dec 17, 2019

Appl. No.:

16/717986

Inventors:

- Singapore, SG
Naoki Iwamoto - Brighton MA, US
Nenad Svrzikapa - Cambridge MA, US
Gregory L. Verdine - Boston MA, US
Ivan Zlatev - Cambridge MA, US

International Classification:

C12N 15/113
C07H 21/00
C07C 317/28
C07D 295/088
C12N 15/11
C12Q 1/6876

Abstract:

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

US Patent:

20210115444, Apr 22, 2021

Filed:

Sep 9, 2020

Appl. No.:

17/016313

Inventors:

- Singapore, SG
David Butler - Medford MA, US
Naoki Iwamoto - Boston MA, US
Nenad Svrzikapa - Cambridge MA, US
Gregory L. Verdine - Boston MA, US
Ivan Zlatev - Cambridge MA, US

International Classification:

C12N 15/113

Abstract:

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

US Patent:

20200080083, Mar 12, 2020

Filed:

Aug 26, 2019

Appl. No.:

16/551503

Inventors:

- Singapore, SG
Nenad Svrzikapa - Cambridge MA, US
Susovan Mohapatra - Belmont MA, US
Christopher J. Francis - Arlington MA, US
Gregory L. Verdine - Boston MA, US
Anna Sokolovska - Somerville MA, US

International Classification:

C12N 15/113
A61P 25/28
C12N 15/115

Abstract:

Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

US Patent:

20200056173, Feb 20, 2020

Filed:

May 3, 2017

Appl. No.:

16/098836

Inventors:

- Singapore, SE
Nenad Svrzikapa - Cambridge MA, US
Susovan Mohapatra - Belmont MA, US
Christopher J. Francis - Arlington MA, US
Gregory L. Verdine - Boston MA, US
Anna Sokolovska - Somerville MA, US

International Classification:

C12N 15/11
C12N 15/113

Abstract:

Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

US Patent:

20180216108, Aug 2, 2018

Filed:

Jul 22, 2016

Appl. No.:

15/746220

Inventors:

Chandra Vargeese - Schwenksville PA, US
Meena - Belmont MA, US
Nenad Svrzikapa - Cambridge MA, US
Susovan Mohapatra - Belmont MA, US
Christopher J. Francis - Arlington MA, US
Gregory L. Verdine - Boston MA, US
Anna Sokolovska - Somerville MA, US

International Classification:

C12N 15/113
A61P 25/28

Abstract:

Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

US Patent:

20170275621, Sep 28, 2017

Filed:

Mar 17, 2017

Appl. No.:

15/462787

Inventors:

- Singapore, SG
Naoki Iwamoto - Brighton MA, US
Nenad Svrzikapa - Cambridge MA, US
Gregory L. Verdine - Boston MA, US
Ivan Zlatev - Cambridge MA, US

International Classification:

C12N 15/113
C07D 295/088
C07H 21/00
C12Q 1/68
C07C 317/28
C12N 15/11

Abstract:

The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.

US Patent:

20170037399, Feb 9, 2017

Filed:

Jan 16, 2015

Appl. No.:

15/112146

Inventors:

- Singapore, SG
David Butler - Medford MA, US
Naoki Iwamoto - Brighton MA, US
Nenad Svrzikapa - Cambridge MA, US
Gregory L. Verdine - Boston MA, US
Ivan Zlatev - Cambridge MA, US

International Classification:

C12N 15/113

Abstract:

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.