Nir W Hacohen

US Patent:

7855074, Dec 21, 2010

Filed:

Apr 28, 2005

Appl. No.:

11/116234

Inventors:

William L. Warren - Orlando FL, US
Heather Fahlenkamp - Oviedo FL, US
Russell Higbee - Orlando FL, US
Anatoly Kachurin - Orlando FL, US
Conan Li - Orlando FL, US
Mike Nguyen - Orlando FL, US
Robert Parkhill - Orlando FL, US
Darrell J. Irvine - Arlington MA, US
Gwendalyn J. Randolph - New York NY, US
Nir Hacohen - Brookline MA, US
Bruce Torbett - Encinitas CA, US

Assignee:

VaxDesign Corp. - Orlando FL

International Classification:

C12N 5/08

US Classification:

435372, 435373

Abstract:

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.

US Patent:

8273357, Sep 25, 2012

Filed:

Jul 18, 2005

Appl. No.:

11/632442

Inventors:

Nir Hacohen - Cambridge MA, US
Eddie Adams - Brighton MA, US
Peter Seeberger - Zurich, CH

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Whitehead Institute for Biomedical Research - Cambridge MA
The General Hospital Corporation - Boston MA

International Classification:

A61K 39/00

US Classification:

4241931, 530300

Abstract:

The present invention generally relates to compositions comprising antigen-carbohydrate conjugates and methods of immune modulation featuring these reagents.

US Patent:

20020192681, Dec 19, 2002

Filed:

Oct 24, 2001

Appl. No.:

10/085982

Inventors:

Nir Hacohen - Cambridge MA, US
Qian Huang - Arlington MA, US
Dongyu Liu - Malden MA, US

Assignee:

Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

Distinct gene expression programs activated in response to different pathogens in dendritic cells are disclosed. Methods of diagnosis and treatment are also disclosed.

US Patent:

20050053667, Mar 10, 2005

Filed:

Jul 9, 2004

Appl. No.:

10/886707

Inventors:

Darrell Irvine - Arlington MA, US
Siddhartha Jain - New Delhi, IN
Nir Hacohen - Cambridge MA, US
William Warren - Orlando FL, US

International Classification:

A61K039/38
A61K039/12
A61K009/16
A61K009/50

US Classification:

424490000, 424204100, 424234100

Abstract:

The present invention provides compositions and methods for modulating immune responses to antigens. One aspect of the present invention relates to a particle-based antigen delivery system (vaccination node) that comprises a hydrogel particle capable of both antigen presentation and DC activation. The VN may further comprise a chemoattractant-loaded microsphere capable of attracting DCs to the site of administration. Another aspect of the present invention relates to the use of the VN to modulate antigen presenting cells activation for the prevention and/treatment of various diseases, such as infectious diseases, cancers and autoimmune diseases.

US Patent:

20060078540, Apr 13, 2006

Filed:

Mar 18, 2003

Appl. No.:

10/508350

Inventors:

William Warren - Orlando FL, US
Nir Hacohen - Cambridge MA, US
Lan Chen - Lexington MA, US
Darell Irvine - Arlington MA, US
Anatoly Kachurin - Orlando FL, US
Russell Higbee - Orlando FL, US
Qian Huang - Arlington MA, US

International Classification:

C12N 5/08
A61K 48/00
A61K 35/14

US Classification:

424093100, 435372000, 424422000

Abstract:

The present invention features dendritic cell nodes that can be used to vaccinate subjects against pathogens and to modulate a subject's immune system to treat or prevent various diseases and conditions.

US Patent:

20110171689, Jul 14, 2011

Filed:

Mar 17, 2010

Appl. No.:

12/725698

Inventors:

William L. Warren - Orlando FL, US
Heather Fahlenkamp - Cleveland OK, US
Russell Higbee - Orlando FL, US
Anatoly Kachurin - Orlando FL, US
Conan Li - Los Altos CA, US
Mike Nguyen - Orlando FL, US
Robert Parkhill - Orlando FL, US
Darrell J. Irvine - Arlington MA, US
Gwendalyn J. Randolph - New York NY, US
Nir Hacohen - Brookline MA, US
Bruce Torbett - Encinitas CA, US

Assignee:

VAXDESIGN CORPORATION - Orlando FL

International Classification:

C12P 21/00

US Classification:

435 704

Abstract:

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.

US Patent:

20110293637, Dec 1, 2011

Filed:

May 16, 2011

Appl. No.:

13/108610

Inventors:

Nir Hacohen - Brookline MA, US
Catherine Ju-Ying Wu - , US

Assignee:

The General Hospital Corporation - Boston MA
Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

A61K 39/395
C12Q 1/68
A61P 37/04
A61P 35/00
A61P 35/02
C40B 20/00
A61K 39/00

US Classification:

4241731, 506 2, 435 611, 4242771, 4241851

Abstract:

The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the invention provides a method of identifying tumor specific neoantigens that alone or in combination with other tumor-associated peptides serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor responses.

US Patent:

20130078656, Mar 28, 2013

Filed:

Sep 10, 2012

Appl. No.:

13/608579

Inventors:

William L. WARREN - Orlando FL, US
Heather FAHLENKAMP - Cleveland OK, US
Russell HIGBEE - Orlando FL, US
Anatoly KACHURIN - Orlando FL, US
Conan LI - Los Altos CA, US
Mike NGUYEN - Orlando FL, US
Robert PARKHILL - Orlando FL, US
Darrell J. IRVINE - Arlington MA, US
Gwendalyn J. RANDOLPH - New York NY, US
Nir HACOHEN - Brookline MA, US
Bruce TORBETT - Encinitas CA, US

Assignee:

SANOFI PASTEUR VAXDESIGN CORPORATION - Orlando FL
THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH - CAMBRIDGE MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE MA
THE SCRIPPS RESEARCH INSTITUTE - LA JOLLA CA

International Classification:

C12N 5/071

US Classification:

435 794, 435 29, 435 792

Abstract:

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.