Norihito Kawasaki

US Patent:

20130164364, Jun 27, 2013

Filed:

Jul 29, 2011

Appl. No.:

13/261581

Inventors:

James C. Paulson - Del Mar CA, US
Weihsu Claire Chen - Toronto, CA
Norihito Kawasaki - San Diego CA, US
Corwin Nycholat - San Diego CA, US

International Classification:

A61K 9/127
A61K 39/00

US Classification:

424450, 4241841, 514 76, 514 44 R, 435375

Abstract:

The present invention provides liposome targeting compounds for targeting cells expressing sialic acid binding Ig-like lectin (Siglec). The liposome compounds typically comprise a binding moiety that is a glycan ligand of the Siglec on the target cell. The liposome compounds also incorporate or encapsulate a biological agent (e.g., an antigen or a therapeutic agent) that can be delivered to the target cell to modulate or kill the target cell. The invention also provides methods of using the liposome targeting compounds for targeted delivery of antigen and for modulating immune cells or immune responses.