Omar S Nourzaie

US Patent:

20150197558, Jul 16, 2015

Filed:

Mar 25, 2015

Appl. No.:

14/668767

Inventors:

- Menlo Park CA, US
Stefan RYSER - Menlo Park CA, US
Angeles ESTELLES - Belmont CA, US
Robert STEPHENSON - Palo Alto CA, US
Reyna J. SIMON - Los Gatos CA, US
Omar NOURZAIE - Santa Clara CA, US

International Classification:

C07K 16/12
A61K 39/40
C12N 15/115
A61K 45/06

Abstract:

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species and decoy nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.

US Patent:

20150086561, Mar 26, 2015

Filed:

Sep 25, 2014

Appl. No.:

14/497147

Inventors:

- SOUTH SAN FRANCISCO CA, US
Stefan RYSER - Menlo Park CA, US
Angeles ESTELLES - Belmont CA, US
Robert STEPHENSON - Palo Alto CA, US
Reyna J. SIMON - Los Gatos CA, US
Omar NOURZAIE - Santa Clara CA, US

International Classification:

C07K 16/12
C07K 14/285
G01N 33/569
A61K 39/104
A61K 39/108
A61K 39/102
C07K 7/08
A61K 39/085

US Classification:

4241391, 5303879, 5303873, 536 2353, 530326, 4241901, 530328, 435331, 435 696, 436501, 435 71, 506 10, 506 9, 435 693, 4352542, 435419

Abstract:

Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.