Paresh S Dalal from 138 Highland Ave, Basking Ridge, NJ 07920, age 58, Phone: 9086269007

Resumes

Paresh Dalal

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Location:

Basking Ridge, NJ

Industry:

Pharmaceuticals

Paresh Dalal

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Us Patents

Method Of Delivering A Bioactive Agent With Porous Β-Tricalcium Phosphate Granules
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US Patent:

7357941, Apr 15, 2008
Filed:

Mar 29, 2005
Appl. No.:

11/093429
Inventors:

Paresh S Dalal - Shrewsbury MA, US
Godofredo R Dimaano - Edison NJ, US
Carol A Toth - Sharon MA, US
Shailesh C Kulkarni - Natick MA, US
Assignee:

Stryker Corporation - Kalamazoo MI
International Classification:

A61F 2/00
C12N 11/14
C07K 17/14
A01N 37/18
A61K 31/7088
US Classification:

424423, 424426, 435176, 514 2, 514 44, 530811
Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

Method Of Forming Bone With Porous Βtricalcium Phosphate Granules
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US Patent:

7390498, Jun 24, 2008
Filed:

Mar 29, 2005
Appl. No.:

11/093818
Inventors:

Paresh S Dalal - Shrewsbury MA, US
Godofredo R Dimaano - Edison NJ, US
Carol A Toth - Sharon MA, US
Shailesh C Kulkarni - Natick MA, US
Assignee:

Stryker Corporation - Kalamazoo MI
International Classification:

A61F 2/00
C12N 11/14
C07K 17/14
US Classification:

424423, 424426, 435176, 530811
Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

Method For Producing Porous Β-Tricalcium Phosphate Granules
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US Patent:

8173149, May 8, 2012
Filed:

Feb 21, 2008
Appl. No.:

12/072105
Inventors:

Paresh S. Dalal - Shrewsbury MA, US
Godofredo R. Diamaano - Edison NJ, US
Shailesh C. Kulkarni - Natick MA, US
Assignee:

Stryker Corporation - Kalamazoo MI
International Classification:

A61F 2/00
C12N 11/14
C07K 17/14
A01N 37/18
A61K 31/7088
US Classification:

424423, 424426, 435176, 514 2, 514 44, 530811
Abstract:

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

Porous Beta-Tricalcium Phosphate Granules And Methods For Producing Same
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US Patent:

20030049328, Mar 13, 2003
Filed:

Mar 2, 2001
Appl. No.:

09/798518
Inventors:

Paresh Dalal - Shrewsbury MA, US
Godofredo Dimaano - Edison NJ, US
Carol Toth - Sharon MA, US
Shailesh Kulkarni - Natick MA, US
International Classification:

A61K009/14
A61K033/42
US Classification:

424/602000
Abstract:

A porous -tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 m, preferably 50-125 m. The porous -TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. The invention provides a kit and an implant device comprising the porous -TCP, and one or more additional components including a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous -TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous -TCP material and inducing bone formation are also provided.

Porous Beta-Tricalcium Phosphate Granules And Methods For Producing Same
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US Patent:

20030180376, Sep 25, 2003
Filed:

Sep 21, 2001
Appl. No.:

09/960789
Inventors:

Paresh Dalal - Shrewsbury MA, US
Godofredo Dimaano - Edison NJ, US
Carol Toth - Sharon MA, US
Shailesh Kulkarni - Natick MA, US
International Classification:

A61K033/06
A61K047/04
A61F002/28
US Classification:

424/602000, 514/770000, 424/422000
Abstract:

A porous -tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 m, preferably 50-125 m. The porous -TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous -TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous -TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous -TCP material and inducing bone formation are also provided.

Antibiotic Calcium Phosphate Coating
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US Patent:

20040131754, Jul 8, 2004
Filed:

Jul 1, 2003
Appl. No.:

10/611147
Inventors:

Joseph Zitelli - River Edge NJ, US
Paul Higham - Ringwood NJ, US
Paresh Dalal - Greenville NC, US
Monica Hawkins - Denville NJ, US
Renwen Zhang - Wayne NJ, US
Assignee:

Howmedica Osteonics Corp. - Allendale NJ
International Classification:

A61L002/00
US Classification:

427/002240
Abstract:

A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.

Antibiotic Calcium Phosphate Coating
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US Patent:

20050169964, Aug 4, 2005
Filed:

Feb 17, 2005
Appl. No.:

11/059864
Inventors:

Joseph Zitelli - River Edge NJ, US
Paul Higham - Ringwood NJ, US
Paresh Dalal - Basking Ridge NJ, US
Christopher Scott - Hackensack NJ, US
Assignee:

Howmedica Osteonics Corp. - Mahwah NJ
International Classification:

A61L002/00
A61K009/14
US Classification:

424423000, 427002240
Abstract:

A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein such as OP-1 protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.