Paul A Cossum

US Patent:

6288042, Sep 11, 2001

Filed:

Feb 3, 1998

Appl. No.:

9/017974

Inventors:

Robert F. Rando - Beaconsfield, CA
Michael E. Hogan - The Woodlands TX
Thomas L. Wallace - The Woodlands TX
Paul A. Cossum - The Woodlands TX

Assignee:

Aronex Pharmaceuticals, Inc. - The Woodlands TX
Baylor College of Medicine - Houston TX

International Classification:

A61K 3170

US Classification:

514 44

Abstract:

Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.

Address:

3 Hermann Museum Cir Dr APT 6409, Houston, TX 77004

Phone:

8583528684

VIN:

JM3ER2WL3A0338638

Make:

MAZDA

Model:

CX-7

Year:

2010