Dr. Stengel graduated from the University of Buffalo, SUNY School of Medicine and Biomedical Sciences in 1995. He works in Camp Springs, MD and specializes in General Practice and Internal Medicine.
Hing Leung Sham - Mundelein IL Daniel W. Norbeck - Crystal Lake IL Xiaoqi Chen - Libertyville IL David A. Betebenner - Gurnee IL Dale J. Kempf - Libertyville IL Thomas R. Herrin - Waukegan IL Gondi N. Kumar - Round Lake Beach IL Stephen L. Condon - Kenosha WI Arthur J. Cooper - Lake Villa IL Daniel A. Dickman - Grayslake IL Steven M. Hannick - Highland Park IL Lawrence Kolaczkowski - Gurnee IL Patricia A. Oliver - Lindenhurst IL Daniel J. Plata - Waukegan IL Peter J. Stengel - Waukegan IL Eric J. Stoner - Kenosha WI Jih-Hua Liu - Greek Oaks IL Ketan M. Patel - Arlington Heights IL
James F. Blake - Longmont CO, US Jay Bradford Fell - Longmont CO, US John P. Fischer - Longmont CO, US Robert Than Hendricks - San Carlos CA, US John E. Robinson - Commerce City CO, US Stacey Renee Spencer - Lyons CO, US Peter J. Stengel - Longmont CO, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07D 417/02 A61K 31/5415
US Classification:
5142242, 544 52
Abstract:
Compounds having the formula I wherein A, m and Rare herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed are processes for making the compounds and synthetic intermediates used in the process.
Macrocyclic Compounds As Inhibitors Of Viral Replication
Lawrence M. Blatt - San Francisco CA, US Steven W. Andrews - Longmont CO, US Kevin R. Condroski - Broomfield CO, US Yutong Jiang - Longmont CO, US April L. Kennedy - Denver CO, US Peter J. Stengel - Longmont CO, US Steven M. Wenglowsky - Boulder CO, US
Assignee:
Intermune, Inc. - Brisbane CA
International Classification:
A61K 38/12
US Classification:
530317
Abstract:
The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Jay Bradford Fell - Longmont CO, US Peter Mohr - Longmont CO, US Peter J. Stengel - Longmont CO, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07D 417/02 A61K 31/5415
US Classification:
5142242, 544 52
Abstract:
Compounds having the formula Ia or Ib wherein R, R, Rand Rare as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
1,1-Dioxo-1H-1Λ-Benzo[D]Isothiazol-3-Yl)-4-Hydroxy-1,5-Dihydro-Pyrrol-2-One Inhibitors Of Hcv Polymerase
James F. Blake - Longmont CO, US Jay Bradford Fell - Longmont CO, US John P. Fischer - Longmont CO, US Robert Than Hendricks - San Carlos CA, US Stacey Renee Spencer - Lyons CO, US Peter J. Stengel - Longmont CO, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A01N 43/80
US Classification:
514373, 548206, 548207
Abstract:
Compounds having the formula i wherein m, R, R, Rand Xare herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.
Hing Leung Sham - Mundelein IL, US Daniel W. Norbeck - Crystal Lake IL, US Xiaoqi Chen - Libertyville IL, US David A. Betebenner - Gurnee IL, US Dale J. Kempf - Libertyville IL, US Thomas R. Herrin - Waukegan IL, US Gondi N. Kumar - Round Lake Beach IL, US Stephen L. Condon - Kenosha WI, US Arthur J. Cooper - Lake Villa IL, US Daniel A. Dickman - Grayslake IL, US Steven M. Hannick - Highland Park IL, US Lawrence Kolaczkowski - Gurnee IL, US Patricia A. Oliver - Lindenhurst IL, US Daniel J. Plata - Wads Worth IL, US Peter J. Stengel - Waukegan IL, US Eric J. Stoner - Kenosha WI, US Jih-Hua Liu - Greek Oaks IL, US Ketan M. Patel - Arlington Heights IL, US
Hing Sham - Mundelein IL, US Daniel Norbeck - Crystal Lake IL, US Xiaoqi Chen - Libertyville IL, US David Betebenner - Gurnee IL, US Dale Kempf - Libertyville IL, US Thomas Herrin - Waukegan IL, US Gondi Kumar - Round Lake Beach IL, US Stephen Condon - Kenosha WI, US Arthur Cooper - Lake Villa IL, US Daniel Dickman - Grayslake IL, US Steven Hannick - Highland Park IL, US Lawrence Kolaczkowski - Gurnee IL, US Patricia Oliver - Lindenhurst IL, US Daniel Plata - Wads Worth IL, US Peter Stengel - Waukegan IL, US Eric Stoner - Kenosha WI, US Jih-Hua Liu - Greek Oaks IL, US Ketan Patel - Arlington Heights IL, US
Ian Mitchell - Lafayette CO, US Keith Spencer - Lyons CO, US Peter Stengel - Longmont CO, US Yongxin Han - Longmont CO, US Nicholas Kallan - Boulder CO, US Mark Munson - Louisville CO, US Guy Vigers - Boulder CO, US James Blake - Longmont CO, US Anthony Piscopio - Longmont CO, US John Josey - Longmont CO, US Scott Miller - Longmont CO, US Dengming Xiao - Longmont CO, US Riu Xu - Longmont CO, US Chang Rao - Waltham MA, US Bin Wang - Longmont CO, US April Bernacki - Longmont CO, US
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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