Shaomeng Wang - Saline MI, US Haiying Sun - Ann Arbor MI, US Dongguang Qin - Ann Arbor MI, US Jianfeng Lu - Ann Arbor MI, US Su Qiu - Ann Arbor MI, US Yuefeng Peng - Ann Arbor MI, US Qian Cai - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A01N 47/10 A61K 31/27 C07D 225/00
US Classification:
514483, 540483
Abstract:
The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Shaomeng Wang - Saline MI, US Yuefeng Peng - Ann Arbor MI, US Haiying Sun - Ann Arbor MI, US Qian Cai - Ann Arbor MI, US Jianfeng Lu - Ann Arbor MI, US Su Qiu - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 31/33 C07D 245/00
US Classification:
514183, 540460
Abstract:
The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Shaomeng Wang - Saline MI, US Haiying Sun - Ann Arbor MI, US Dongguang Qin - Ann Arbor MI, US Jianfeng Lu - Ann Arbor MI, US Su Qiu - Ann Arbor MI, US Yuefeng Peng - Ann Arbor MI, US
Assignee:
Regents of the University of Michigan - Ann Arbor MI
The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Shaomeng Wang - Saline MI, US Yuefeng Peng - Ann Arbor MI, US Haiying Sun - Ann Arbor MI, US Qian Cai - Ann Arbor MI, US Jianfeng Lu - Ann Arbor MI, US Su Qiu - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
C07D 487/04
US Classification:
540460
Abstract:
The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.