Rachel D Kimmich

US Patent:

20070259354, Nov 8, 2007

Filed:

Sep 28, 2006

Appl. No.:

11/536394

Inventors:

Guy Servant - San Diego CA, US
Paul Brust - San Diego CA, US
Bryan Moyer - San Diego CA, US
Min Lu - San Diego CA, US
Fernando Echeverri - Chula Vista CA, US
David Dahan - Oceanside CA, US
Mark Zoller - La Jolla CA, US
Mark Williams - Carlsbad CA, US
Rachel Kimmich - Carlsbad CA, US
Poonit Kamdar - San Diego CA, US
Tanya Ditschun - San Diego CA, US
Andrew Patron - San Marcos CA, US

Assignee:

Senomyx, Inc. - San Diego CA

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04
C12N 15/85
C12N 5/10

US Classification:

435006000, 435320100, 435358000, 435363000, 435365000, 435366000, 435367000, 536023100, 536024100

Abstract:

Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.

US Patent:

20110224155, Sep 15, 2011

Filed:

Jun 3, 2008

Appl. No.:

12/663634

Inventors:

Catherine Tachdjian - San Diego CA, US
Donald S. Karanewsky - Escondido CA, US
Xiao-Qing Tang - San Diego CA, US
Xiaodong Li - San Diego CA, US
Feng Zhang - San Diego CA, US
Guy Servant - San Diego CA, US
Qing Chen - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Richard Fine - Ridgewood NJ, US
Joseph R. Fotsing - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Xinshan Kang - Pine Brook NJ, US
Rachel D.A. Kimmich - San Diego CA, US
Boris Klebansky - Demarest NJ, US
Haitian Liu - San Diego CA, US
Goran Petrovic - San Diego CA, US
Jeffrey Yamamoto - San Diego CA, US
Hong Zhang - San Diego CA, US
Albert Zlotnik - San Diego CA, US
Mark Zoller - La Jolla CA, US
Karen Zoller - La Jolla CA, US

Assignee:

SENOMYX INC. - San Diego CA

International Classification:

A61K 31/517
C12N 5/00
C07D 495/04
A61K 31/519
C07D 239/95
C07D 285/16
A61K 31/54
C07D 471/04
C07D 215/42
A61K 31/4706
C07D 513/04
C07D 513/20
C07H 17/02
A61K 31/706
A61P 27/00
A23L 1/226
G06G 7/58

US Classification:

514 25, 435375, 544278, 5142581, 5142663, 544286, 544250, 514267, 544 11, 5142228, 5142664, 544291, 544279, 51426411, 546157, 514312, 544 9, 544 6, 536 173, 426536, 426442, 703 11

Abstract:

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

US Patent:

20070003680, Jan 4, 2007

Filed:

Jun 15, 2006

Appl. No.:

11/455314

Inventors:

Catherine Tachdjian - San Diego CA, US
Andrew Patron - San Marcos CA, US
Farid Bakir - San Diego CA, US
Claudia Averbuj - San Diego CA, US
Chad Priest - Encinitas CA, US
Qing Chen - San Diego CA, US
Vincent Darmohusodo - San Diego CA, US
Rachel Kimmich - Carlsbad CA, US
Xiao-Qing Tang - San Deigo CA, US
Rhondi Shigemura - Encinitas CA, US

International Classification:

A23L 1/236

US Classification:

426548000

Abstract:

The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

US Patent:

20200010425, Jan 9, 2020

Filed:

Sep 18, 2019

Appl. No.:

16/574657

Inventors:

- Plainsboro NJ, US
Andrew Patron - San Marcos CA, US
Chad Priest - Cardiff CA, US
Donald Karanewsky - Escondido CA, US
Rachel Kimmich - San Diego CA, US
Brant Clayton Boren - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Volodymyr Chumakov - San Diego CA, US
Wen Zhao - San Diego CA, US
Alain Noncovich - San Diego CA, US
Jane Ung - San Diego CA, US

International Classification:

C07D 231/20
A23L 33/10
C07D 333/22
C07D 233/78
C07D 235/02
C07D 401/06
C07D 403/06
C07D 239/22
C07D 405/06
C07D 409/06
C07D 207/32
C07D 213/50
A23L 2/52
C07C 233/31
C07D 207/26
C07D 207/333
C07D 239/62

Abstract:

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

US Patent:

20170369447, Dec 28, 2017

Filed:

Sep 6, 2017

Appl. No.:

15/697301

Inventors:

- San Diego CA, US
Andrew Patron - San Marcos CA, US
Chad Priest - Cardiff CA, US
Donald Karanewsky - Escondido CA, US
Rachel Kimmich - San Diego CA, US
Brant Clayton Boren - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Volodymyr Chumakov - San Diego CA, US
Wen Zhao - San Diego CA, US
Alain Noncovich - San Diego CA, US
Jane Ung - San Diego CA, US

International Classification:

C07D 231/20
A23L 33/10
C07D 403/06
C07D 401/06
C07D 333/22
C07D 239/62
C07D 239/22
C07D 235/02
C07D 233/78
C07D 213/50
C07D 207/333
C07D 207/32
C07D 207/26
C07C 233/31
C07D 405/06
A23L 2/52
C07D 409/06
C07C 2601/04
C07C 2601/16

Abstract:

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

US Patent:

20170029416, Feb 2, 2017

Filed:

Oct 11, 2016

Appl. No.:

15/290691

Inventors:

- San Diego CA, US
Vincent Darmohusodo - Encinitas CA, US
Catherine Tachdjian - San Diego CA, US
Donald Karanewsky - Escondido CA, US
Goran Petrovic - San Diego CA, US
Rachel Kimmich - San Diego CA, US
Joseph R. Fotsing - San Diego CA, US

International Classification:

C07D 417/12
A23L 27/20
C07D 473/00
C07D 498/04
C07D 417/14
C07D 471/04

Abstract:

The present invention includes compounds having structural formula (Ia):

US Patent:

20160339026, Nov 24, 2016

Filed:

Oct 2, 2015

Appl. No.:

14/874258

Inventors:

- San Diego CA, US
Jane Ung - San Diego CA, US
Timothy Davis - Santee CA, US
Joseph R. Fotsing - San Diego CA, US
Rachel D.A. Kimmich - San Diego CA, US
Chad Priest - Leucadia CA, US
Donald S. Karanewsky - Escondido CA, US
Lyudmyla Chumakova - San Diego CA, US
Andrew Patron - San Marcos CA, US
Paul Brust - San Diego CA, US
Guy Servant - San Diego CA, US

International Classification:

A61K 31/515
A61K 31/4155
A61K 31/4152
A61K 31/4406
A61K 31/513
A61K 31/4166
A61K 31/165
A61K 9/00
A61K 31/4439

Abstract:

The present disclosure relates to topical compositions comprising one or more compounds which are cooling agents.

US Patent:

20150376136, Dec 31, 2015

Filed:

Feb 19, 2014

Appl. No.:

14/768146

Inventors:

- San Diego CA, US
Andrew Patron - San Marcos CA, US
Chad Priest - Cardiff CA, US
Donald Karanewsky - Escondido CA, US
Rachel Kimmich - San Diego CA, US
Brant Clayton Boren - San Diego CA, US
Jeffrey Robert Hammaker - San Diego CA, US
Volodymyr Chumakov - San Diego CA, US
Wen Zhao - San Diego CA, US
Alain Noncovich - San Diego CA, US
Jane Ung - San Diego CA, US

International Classification:

C07D 231/20
C07D 405/06
C07D 403/06
C07D 401/06
C07D 239/22
A23L 2/52
C07C 233/31
C07D 213/50
C07D 333/22
C07D 207/26
C07D 207/333
A23L 1/30
C07D 409/06
C07D 239/62

Abstract:

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.