Ralph Leonard Somack

US Patent:

20030098271, May 29, 2003

Filed:

Nov 26, 2001

Appl. No.:

09/994495

Inventors:

Ralph Somack - Oakland CA, US
Gary Lim - San Francisco CA, US

International Classification:

C12Q001/68
C02F001/44

US Classification:

210/295000, 435/006000

Abstract:

The present invention relates to a biological sample collection, archiving, purification, and manipulating system and methods for collecting, archiving, purifying, and manipulating biological samples. The system can include a plurality of devices, each having a species-immobilizing filter within a tubular body. The body includes first and second end openings and one or more removable caps or sealing devices for sealing the end openings. A plurality of the devices can be positioned in an array tray for simultaneously archiving, purifying, or reacting respective samples collected in the respective devices. In another embodiment, a plate system is provided that includes a plate having a plurality of through-holes with each through-hole having a species-immobilizing filter disposed therein. The plate system also includes sealing devices such as sealing trays or removable caps for sealing first and second end openings of each through-hole of the plate.

US Patent:

20070003443, Jan 4, 2007

Filed:

Jun 23, 2006

Appl. No.:

11/426289

Inventors:

Donald Sandell - San Jose CA, US
Ralph Somack - Oakland CA, US
Ian Harding - San Mateo CA, US
Dennis Lehto - Santa Clara CA, US

Assignee:

APPLERA CORPORATION - Foster City CA

International Classification:

B01L 3/02

US Classification:

422100000

Abstract:

A pipette tip and system for aspiration of a biological sample, distribution to a plurality of sample chambers, and thermal cycling in the pipette tip.

US Patent:

20070190522, Aug 16, 2007

Filed:

Mar 19, 2007

Appl. No.:

11/725301

Inventors:

Ralph Somack - Oakland CA, US
Gary Lim - San Francisco CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12Q 1/00
C12Q 1/68
A01N 1/02

US Classification:

435004000, 435006000, 435002000

Abstract:

The present invention relates to a biological sample collection, archiving, purification, and manipulating system and methods for collecting, archiving, purifying, and manipulating biological samples. The system can include a plurality of devices, each having a species-immobilizing filter within a tubular body. The body includes first and second end openings and one or more removable caps or sealing devices for sealing the end openings. A plurality of the devices can be positioned in an array tray for simultaneously archiving, purifying, or reacting respective samples collected in the respective devices. In another embodiment, a plate system is provided that includes a plate having a plurality of through-holes with each through-hole having a species-immobilizing filter disposed therein. The plate system also includes sealing devices such as sealing trays or removable caps for sealing first and second end openings of each through-hole of the plate.

US Patent:

50063332, Apr 9, 1991

Filed:

Jul 13, 1989

Appl. No.:

7/380205

Inventors:

Mark Saifer - Berkeley CA
Ralph Somack - Oakland CA
L. David Williams - Fremont CA

Assignee:

DDI Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 3174
A61K 3748

US Classification:

424 78

Abstract:

A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.

US Patent:

59726130, Oct 26, 1999

Filed:

Dec 9, 1997

Appl. No.:

8/987329

Inventors:

Ralph Somack - Oakland CA
Stephen E. Moring - Moss Beach CA

Assignee:

The Perkin-Elmer Corporation - Foster City CA

International Classification:

C12Q 168
C12N 1510

US Classification:

435 6

Abstract:

The invention relates to new methods of RNA isolation that exploit the surprising discovery that RNA may be differentially precipitated from DNA. The subject methods result in the formation of an RNA-containing precipitate that has an RNA content at least two fold enriched with respect to DNA, as compared with the RNA to DNA ratio of the solution from which the RNA-containing precipitate is derived. The invention also includes various methods of DNA isolation that employ the selective precipitation of RNA. The degree of RNA enrichment achieved is often much greater than two fold; enrichment by a factor of ten or greater is frequently obtained. By precipitating RNA from a solution, the RNA may be collected by simple procedures such as centrifugation or filtration, thereby avoiding the need to bind the RNA to solid phase. The collected RNA precipitate may then be solubilized. One embodiment of the subject methods involves forming an RNA-containing nucleic acid composition, adding an RNA precipitate forming chaotropic salt to the nucleic acid composition in a sufficient concentration to form an RNA-containing precipitate, collecting the RNA-containing precipitate, and (optionally) solubilizing the precipitate.

US Patent:

50808915, Jan 14, 1992

Filed:

Aug 1, 1990

Appl. No.:

7/560996

Inventors:

Mark Saifer - Berkeley CA
Ralph Somack - Oakland CA
L. David Williams - Fremont CA

Assignee:

DDI Pharmaceuticals, Inc. - Mountain View CA

International Classification:

A61K 3174
A61K 3748

US Classification:

424 783

Abstract:

A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.

US Patent:

52833178, Feb 1, 1994

Filed:

Oct 11, 1991

Appl. No.:

7/774841

Inventors:

Mark Saifer - Berkeley CA
Ralph Somack - Oakland CA
L. David Williams - Fremont CA

Assignee:

DDI Pharmaceuticals, Inc. - Mountain View CA

International Classification:

C07D20746
C08G 5900

US Classification:

528405

Abstract:

A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.

US Patent:

54684781, Nov 21, 1995

Filed:

Oct 18, 1993

Appl. No.:

8/138301

Inventors:

Mark Saifer - Berkeley CA
Ralph Somack - Oakland CA
L. David Williams - Fremont CA

Assignee:

Oxis International, Inc. - Portland OR

International Classification:

A61K 31765

US Classification:

424 7827

Abstract:

A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said polyalkylene glycol has an average molecular weight of about 35,000-1,000,000.