Jan Blusztajn - Cambridge MA, US Raul Krauss - Cambridge MA, US R. Thies - Andover MA, US
International Classification:
A61K038/17
US Classification:
514012000
Abstract:
BMP-9 compositions and methods for their use are disclosed. The BMP-9 compositions act as a differentiating factor for the cholinergic phenotype of CNS neurons. The compositions may be used in the treatment of diseases and disorders caused by degeneration and/or malfunctioning of cholinergic neurons.
Cell Adhesion-Mediating Proteins And Polynucleotides Encoding Them
Karen Stark - Arlington MA, US Alix Weaver - Northbridge MA, US Heidi Hoffmann - Lunenberg MA, US Raul Krauss - Newton MA, US Kulvinder Saini - Haryana, IN Dario Valenzuela - Houston TX, US
The present invention provides multiple polynucleotide sequences from the same novel gene, the exons comprising the polynucleotide sequences, and the proteins encoded by the polynucleotide sequences. Three splicing variant polynucleotides were isolated from prostate tissue. The polypeptides, including the splicing variants, have a region of hydrophobicity indicative of a transmembrane domain and all three extracellular and cytoplasmic domains.
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