Richard C Ascione from Manchester, NJ, age 67

Address:

Howell, NJ

License #:

34EI00951400 - Expired

Category:

Electrical Contractors

Issued Date:

Mar 5, 1989

Expiration Date:

Mar 31, 2009

Type:

Electrical Contractor

Address:

Howell, NJ

License #:

34EI00951400 - Expired

Category:

Electrical Contractors

Issued Date:

Mar 5, 1989

Expiration Date:

Mar 31, 2009

Type:

Electrical Contractor

Immunogenic Compositions Against Human Progastrin Peptides
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US Patent:

20130064841, Mar 14, 2013
Filed:

Aug 31, 2012
Appl. No.:

13/601106
Inventors:

Richard Ascione - Jersey City NJ, US
Shengmei Qi - Jersey City NJ, US
Bin Wang - Jersey City NJ, US
International Classification:

C07K 14/435
C07K 7/06
A61P 37/04
A61K 39/00
US Classification:

4241851, 530324, 530329
Abstract:

Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.