Lyell Immunopharma
Chief Information Officer
Lyell Immunopharma Dec 2018 - Apr 2019
Svp, Information Sciences
Station X 2010 - 2018
Founder and Chief Executive Officer
Incyte 2002 - 2004
Svp, Chief Genomics Officer
Prospect Genomics 2000 - 2002
Founder and President
Education:
University of Cape Town 1984 - 1989
Doctorates, Doctor of Philosophy, Biochemistry
Rhodes University 1983 - 1984
Rhodes University 1980
Skills:
Genomics Bioinformatics Biotechnology Drug Discovery Molecular Biology Genetics Life Sciences Lifesciences Computational Biology Sequencing Dna Sequencing Biochemistry Cancer Personalized Medicine Dna Biomarkers Commercialization Oncology Biopharmaceuticals Systems Biology Immunology Cell Biomarker Discovery
Philippe E. Rigault - Palo Alto CA Anne L. Curtis - Pacifica CA Richard D. Goold - Belmont CA David A. Hadley - Palo Alto CA Harold H. Hibbert - Fremont CA Tod M. Klingler - San Carlos CA Robert E. Lagace - San Francisco CA Laura L. Stuve - Los Gatos CA Michael G. Walker - Sunnyvale CA Michael P. Wood - San Francisco CA
Assignee:
Incyte Pharmaceuticals, Inc. - Palo Alto CA
International Classification:
G06F 1730
US Classification:
7071041, 707 6, 707100, 702 19, 435 6
Abstract:
A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
Database For Storage And Analysis Of Full-Length Sequences
Stephen Lincoln - Redwood City CA, US Tod Klingler - San Carlos CA, US Janice Au-Young - Berkeley CA, US Y. Tang - San Jose CA, US Richard Goold - San Francisco CA, US Ingrid Akerblom - Redwood City CA, US Jeffrey Seilhamer - Los Altos Hills CA, US Phillip Hawkins - Mountain View CA, US Lynn Murry - Portola Valley CA, US Angelo Delegeane - Milipitas CA, US Wendy Levine - Mountain View CA, US Jennifer Hillman - Mountain View CA, US Surya Goli - San Jose CA, US Christina Altus - Palo Alto CA, US Olga Bandman - Mountain View CA, US Samuel LaBrie - O'Fallon MO, US Purvi Shah - Sunnyvale CA, US
International Classification:
C12Q001/68 G06F019/00 G01N033/48 G01N033/50
US Classification:
435/006000, 702/020000
Abstract:
The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
The invention provides a cDNA which encodes a tumor suppressor. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.
Database For Storage And Analysis Of Full-Length Sequences
Steve E. Lincoln - Redwood City CA Tod M. Klingler - San Carlos CA Janice Au-Young - Berkeley CA Y. Tom Tang - San Jose CA Richard D. Goold - San Francisco CA Ingrid E. Akerblom - Redwood City CA Jeffrey J. Seilhamer - Los Altos Hills CA Phillip R. Hawkins - Mountain View CA Lynn E. Murry - Portola Valley CA Angelo M. Delegeane - Milpitas CA Wendy B. Levine - Mountain View CA Jennifer L. Hillman - Mountain View CA Surya K. Goli - San Jose CA Christina M. Altus - Palo Alto CA Olga Bandman - Mountain View CA Samuel T. LaBrie - O'Fallon MO Purvi Shah - Sunnyvale CA
Assignee:
Incyte Pharmaceuticals, Inc. - Palo Alto CA
International Classification:
C12Q 168
US Classification:
435 6
Abstract:
The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
Polynucleotides Panc1A And Panc1B Associated With Pancreatic Cancer
Richard D. Goold - San Francisco CA Ingrid E. Akerblom - Redwood City CA Jeffrey J. Seilhamer - Los Altos Hills CA
Assignee:
Incyte Pharmaceuticals, Inc. - Palo Alto CA
International Classification:
C12N 1511 C12N 1566 C12N 1585 C07H 2104
US Classification:
536 235
Abstract:
The present invention provides polynucleotide sequences designated PANC1A and PANC1B which are associated with a genomic sequence related to pancreatic cancer as well as other cancers. The present invention also provides for PANC1A and PANC1B antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified PANC1A and PANC1B polypeptide; antibodies, antagonists and inhibitors of PANC1A and PANC1B polypeptide; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as a diagnostic composition for the detection of pancreatic cancer in individuals at risk for and subject to pancreatic cancer. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for PANC1A and PANC1B.
System And Method For A Precompiled Database For Biomolecular Sequence Information
Philippe E. Rigault - Palo Alto CA Anne L. Curtis - Pacifica CA Richard D. Goold - Belmont CA David A. Hadley - Palo Alto CA Harold H. Hibbert - Fremont CA Tod M. Klingler - San Carlos CA Robert E. Lagace - San Francisco CA Laura L. Stuve - Los Gatos CA Michael G. Walker - Sunnyvale CA Michael P. Wood - San Francisco CA
Assignee:
Incyte Pharmaceuticals, Inc. - Palo Alto CA
International Classification:
G06F 1730
US Classification:
707104
Abstract:
A computer system stores biomolecular data in a database in a memory. The biomolecular database has a set of entities. Each entity stores attributes for a plurality of entries. At least one attribute is stored in an array. Data associated with an entry is stored at a location in the array. An entity offset designates the location of the data in the array. The same entity offset value is used to access data associated with a particular entry for all attributes within the entity.
Polynucleotides Encoding A Protein Associated With Pancreatic Cancer
Richard D. Goold - San Francisco CA Ingrid E. Akerblom - Redwood City CA Jeffrey J. Seilhamer - Los Altos Hills CA Roger Coleman - Mountain View CA
Assignee:
Incyte Pharmaceuticals, Inc. - Palo Alto CA
International Classification:
C12N 1512
US Classification:
435 691
Abstract:
The present invention provides polynucleotides and related reagents which are associated with pancreatic and other cancers. These polynucleotides are designated PANC1A.
Janice Au-Young - Berkley CA Richard D. Goold - San Francisco CA
Assignee:
Incyte Genomics, Inc. - Palo Alto CA
International Classification:
C12Q 168 C12P 1934
US Classification:
435 6
Abstract:
The present invention provides nucleotide and amino acid sequences for a novel PAC10 human homolog. The present invention also provides for antisense molecules, diagnostic molecules, genetically engineered expression vectors and host cells for the production of purified PAC10 homologs; antibodies, agonists, antagonists and inhibitors of the PAC10 human homolog; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, ntagonists and inhibitors. The invention further provides diagnostic and theapeutic compositions for the detection and treatment of X-linked congenital abnormalities, such as centronuclear myopathy.