Richard P. Polniaszek - Foster City CA Xuebao Wang - East Brunswick NJ John K. Thottathil - Ivanhoe IL Theodor Denzel - Regensburg, DE
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D41312
US Classification:
548235
Abstract:
Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
Process For Preparing The Antiviral Agent [1S-(1Alpha,3 Alpha,4Beta )]-2-Amino-1,9-Dihydro-9-[4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl]-6H-Purin-6-One
Yadagiri R. Pendri - South Glastonbury CT, US Chung-Pin H. Chen - Madison CT, US Sunil S. Patel - Fords NJ, US Jeffrey M. Evans - Manlius NY, US Jing Liang - Princeton NJ, US David R. Kronenthal - Yardley PA, US Gerald L. Powers - North Brunswick NJ, US Siva Josyula Prasad - Kendall Park NJ, US Jeffrey T. Bien - Princeton NJ, US Zhongping Shi - West Windsor NJ, US Ramesh N. Patel - Bridgewater NJ, US Amit Banerjee - St. Louis MO, US Yeung Yu Chan - Kendall Park NJ, US Sushil K. Rijhwani - Robbinsville NJ, US Ambarish K. Singh - Bordentown NJ, US Shaopeng Wang - King of Prussia PA, US Milan Stojanovic - Fort Lee NJ, US David J. Kucera - Del Mar CA, US Richard P. Polniaszek - Redwood City CA, US Charles Lewis - Fairfield NJ, US John Thottathil - Ivanhoe IL, US Maotang X. Zhou - Jamesville NY, US Purushotham Vemishetti - East Syracuse NY, US
Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
Intermediates In The Preparation Of The Antiviral Agent [1S-(1Α, 3Α, 4Β)]-2-Amino-1,9-Dihydro-9-[4-Hydroxy-3-(Hydroxmethyl)-2-Methylenecyclopentyl]-6H-Purin-6-One
Yadagiri R. Pendri - South Glastonbury CT, US Chung-Pin H. Chen - Madison CT, US Jing Liang - Princeton NJ, US Shaopeng Wang - King of Prussia PA, US Milan Stojanovic - Fort Lee NJ, US Richard P. Polniaszek - Redwood City CA, US John Thottathil - Ivanhoe IL, US
Intermediates useful in the preparation of the antiviral agent entecavir are disclosed. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various processes useful in the preparation of entecavir are also disclosed.
Process For Preparation Of Hiv Protease Inhibitors
Kenneth R. Crawford - Burke VA, US Eric Dowdy - Foster City CA, US Arnold Gutierrez - San Jose CA, US Richard P. Polniaszek - Redwood City CA, US Richard Hung Chiu Yu - San Francisco CA, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
A61K 31/665
US Classification:
514100
Abstract:
A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
Process For Preparation Of Hiv Protease Inhibitors
Kenneth R. Crawford - Westwood MA, US Eric D. Dowdy - Foster City CA, US Arnold Gutierrez - San Jose CA, US Richard P. Polniaszek - Half Moon Bay CA, US Richard Hung Chiu Yu - San Francisco CA, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07C 381/00
US Classification:
564 89
Abstract:
A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.
Methods And Intermediates For Preparing Pharmaceutical Agents
Richard Polniaszek - Foster City CA, US Steven Pfeiffer - Foster City CA, US Richard Yu - Foster City CA, US Aaron Cullen - Foster City CA, US Eric Dowdy - Foster City CA, US Duong Tran - Edmonton, CA Kenneth Kent - Foster City CA, US Zhongxin Zhou - Edmonton, CA Doug Cordeau - Foster City CA, US Leah Easton - Foster City CA, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07C 307/06 C07D 413/14
US Classification:
564 79, 544133
Abstract:
The invention provides methods and intermediates that are useful for preparing a compound of formula I:.
Processes And Intermediates Useful For Preparing Integrase Inhibitor Compounds
Jared Evans - Foster City CA, US Jay Parrish - Redwood City CA, US Dominika Pcion - Half Moon Bay CA, US Richard Polniaszek - Redwood City CA, US Christina Schmidt - Belmont CA, US Richard Yu - San Francisco CA, US Vahid Zia - San Carlos CA, US
International Classification:
A61K 31/44 A61P 31/18 C07D 471/04
US Classification:
514292000, 546084000
Abstract:
The invention provides processes and intermediates useful for preparing integrase inhibiting compounds.
Benjamin R. Graetz - San Mateo CA, US Richard Polniaszek - Redwood City CA, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
A61K 31/675 C07F 9/04 A61P 31/18
US Classification:
514 81, 544244
Abstract:
The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to processes and intermediates useful for preparing such salts.