Ronald H Hoffman

US Patent:

6900017, May 31, 2005

Filed:

Jan 10, 2002

Appl. No.:

10/043774

Inventors:

Arun Sharma - Oak Park IL, US
Ronald Hoffman - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C12Q001/68
C12N001/00
C12N005/10
C12N015/12
C12N015/63

US Classification:

435 6, 435243, 4353201, 435325, 435419, 536 235

Abstract:

The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding a human hiwi gene. Also provided are recombinant expression constructs capable of expressing the human hiwi gene of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human hiwi proteins encoded therein. The invention also provides methods for isolating human hematopoietic stem cells.

US Patent:

7612167, Nov 3, 2009

Filed:

May 31, 2005

Appl. No.:

11/141072

Inventors:

Arun Sharma - Oak Park IL, US
Ronald Hoffman - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

C07K 14/435
C07K 14/47
C07K 14/475
C12N 5/00
C12N 5/06
C12N 5/08

US Classification:

530350, 435325, 435366

Abstract:

The present invention relates to novel human hiwi protein and genes that encode such proteins. The invention is directed toward the isolation and characterization of human hiwi proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to a human hiwi gene. Also provided are recombinant expression constructs capable of expressing the human hiwi gene of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the human hiwi proteins encoded therein. The invention also provides methods for isolating human hematopoietic stem cells.

US Patent:

7927785, Apr 19, 2011

Filed:

May 12, 2005

Appl. No.:

11/128128

Inventors:

Mohammed Milhem - Chicago IL, US
Nadim Mahmud - Chicago IL, US
Donald Lavelle - Park Ridge IL, US
Yogen Saunthararajah - Chicago IL, US
Joseph De Simone - Chicago IL, US
Ronald Hoffman - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A01N 1/02
A61K 48/00

US Classification:

435 2, 435 11, 424 931

Abstract:

The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic megakaryocyte progenitor cells are also provided. Compositions enriched for stem cells and populations of cells obtained therefrom are also provided by the invention.

US Patent:

20020152196, Oct 17, 2002

Filed:

Jul 2, 2001

Appl. No.:

09/897798

Inventors:

Carol Westbrook - Chicago IL, US
Ronald Hoffman - Chicago IL, US

International Classification:

G06F007/00

US Classification:

707/001000

Abstract:

A unique database, a “transcriptosome” of a primate CD34+ cell, was compiled which is useful for the analysis and transplantation of bone marrow. Research and clinical applications arise from analysis of bone marrow, and related hemotopoietic tissues, prior to gene therapy or transplantation. Because the database contains many unknown and uncharacterized genes, an important use is the discovery of new genes that are relevant to hematopoiesis and stem cell growth. These genes may lead to further commercial products.

US Patent:

20030105594, Jun 5, 2003

Filed:

Jun 18, 2002

Appl. No.:

10/174513

Inventors:

Carol Westbrook - Chicago IL, US
Ronald Hoffman - Chicago IL, US

International Classification:

G06F019/00
G01N033/48
G01N033/50

US Classification:

702/019000, 702/020000

Abstract:

A unique database, a “transcriptosome” of a primate CD34+ cell, was compiled which is useful for the analysis and transplantation of bone marrow. Research and clinical applications arise from analysis of bone marrow, and related hemotopoietic tissues, prior to gene therapy or transplantation. Because the database contains many unknown and uncharacterized genes, an important use is the discovery of new genes that are relevant to hematopoiesis and stem cell growth. These genes may lead to further commercial products.

US Patent:

20080226612, Sep 18, 2008

Filed:

Aug 2, 2006

Appl. No.:

12/064034

Inventors:

Avraham Treves - Mevaseret Zion, IL
Ronald Hoffman - Chicago IL, US
Arnon Nagler - Jerusalem, IL
Ami Treves - Minneapolis MN, US

Assignee:

Bio Regenerate, Inc. - Minneapolis

International Classification:

C12N 5/06
A61K 48/00
A61K 35/14
A61P 19/00
A61P 25/00
A61P 17/00
A61P 17/02
A61P 1/16
A61P 9/00
A61P 7/06

US Classification:

424 9321, 435347, 435395, 435374, 424 937

Abstract:

The present disclosure covers compositions and method for the preparation and use of mixtures of adult stem/progenitor cell populations recovered and enriched from specific tissues with very limited attempts for their purification. Such mixtures of cell populations have improved therapeutic effectiveness in the treatment of certain diseases and tissue regeneration treatments over their more purified counterpart cell populations. Such mixtures of cell populations can be cryopreserved for future clinical use.

US Patent:

20130291366, Nov 7, 2013

Filed:

May 6, 2013

Appl. No.:

13/887372

Inventors:

Ronald A. Hoffman - Lake Zurich IL, US

International Classification:

F16B 35/04

US Classification:

2952502, 24303

Abstract:

An apparatus and method are provided for affixing an object to a surface. In an exemplary embodiment, the apparatus includes a magnet formed with an opening at its center. The magnet is attached to the surface by inserting a screw into the opening. A spacer and a flat washer are attached to the screw, with the spacer being positioned between the flat washer and the magnet. After the screw is affixed to the surface, a metal object can be magnetically attached to the screw and magnet to secure the object to the surface. A backer plate is also contemplated for securing non-magnetic objects to the screw and magnet. Multiple backer plates can be affixed to objects to support a greater amount of weight if required.

US Patent:

20190345448, Nov 14, 2019

Filed:

Aug 4, 2017

Appl. No.:

16/322584

Inventors:

- New York NY, US
Ronald Hoffman - New York NY, US

International Classification:

C12N 5/078
A61K 35/19

Abstract:

The invention is directed to production of megakaryocyte (MK) compositions and their the treatment of thrombocytopenia in a subject in need thereof.

Author:

Ronald L. Hoffman

ISBN #:

0671646427

Author:

Ronald L. Hoffman

ISBN #:

0671679635

Author:

Ronald L. Hoffman

ISBN #:

0671682342

Author:

Ronald L. Hoffman

ISBN #:

0671734253

Author:

Ronald L. Hoffman

ISBN #:

0671781391

Author:

Ronald L. Hoffman

ISBN #:

0671868128

Author:

Ronald L. Hoffman

ISBN #:

0684810824

Author:

Ronald L. Hoffman

ISBN #:

0879836172