Samar A Jasser

US Patent:

6482795, Nov 19, 2002

Filed:

Aug 26, 1998

Appl. No.:

09/140749

Inventors:

Peter Steck - Bellaire TX
Mark A. Pershouse - Houston TX
Samar A. Jasser - Houston TX
Alfred W. K. Yung - Houston TX
Sean V. Tavtigian - Salt Lake City UT

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT
Board of Regents, University of Texas System - Austin TX

International Classification:

A61K 3800

US Classification:

514 2, 514 12, 514 21, 530350

Abstract:

A specific region of chromosome 10 (10q23. 3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23. 3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23. 3, also are disclosed.

US Patent:

7129040, Oct 31, 2006

Filed:

Nov 1, 2004

Appl. No.:

10/979642

Inventors:

Peter Steck - Bellaire TX, US
Mark A. Pershouse - Houston TX, US
Samar A. Jasser - Houston TX, US
Alfred W. K. Yung - Houston TX, US
Sean V. Tavtigian - Salt Lake City UT, US

International Classification:

C12Q 1/68
G01N 33/53
G01N 33/48
G01N 33/566

US Classification:

435 4, 435 6, 435 71, 436 64, 436501

Abstract:

A specific region of chromosome 10 (10q23. 3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23. 3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23. 3, also are disclosed.

US Patent:

7217795, May 15, 2007

Filed:

Nov 19, 2002

Appl. No.:

10/299003

Inventors:

Peter Steck - Bellaire TX, US
Mark A. Pershouse - Houston TX, US
Samar A. Jasser - Houston TX, US
Alfred W. K. Yung - Houston TX, US
Sean V. Tavtigian - Salt Lake City UT, US

Assignee:

Myriad Genetics, Inc. - Salt Lake City UT
Board of Regents, The University of Texas Systems - Austin TX

International Classification:

C07K 16/00

US Classification:

5303873, 530350, 530380, 530385, 5303871, 5303881, 5303882, 5303884, 4241341, 4241411, 4241351, 424 91, 435188, 435 91

Abstract:

A specific region of chromosome 10 (10q23. 3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23. 3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23. 3, also are disclosed.

US Patent:

7732576, Jun 8, 2010

Filed:

Oct 30, 2006

Appl. No.:

11/590556

Inventors:

Peter Steck - Bellaire TX, US
Mark A. Pershouse - Houston TX, US
Samar A. Jasser - Houston TX, US
Alfred W. K. Yung - Houston TX, US
Sean V. Tavtigian - Lyons, FR

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07K 16/00

US Classification:

5303871, 530350, 5303873, 5303879, 5303881

Abstract:

A specific region of chromosome 10 (10q23. 3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23. 3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23. 3, also are disclosed.

US Patent:

20070048811, Mar 1, 2007

Filed:

Oct 30, 2006

Appl. No.:

11/590578

Inventors:

Peter Steck - Bellaire TX, US
Mark Pershouse - Houston TX, US
Samar Jasser - Houston TX, US
Alfred Yung - Houston TX, US
Sean Tavtigian - Lyon, FR

Assignee:

Myriad Genetics, Incorporated - Salt Lake City UT

International Classification:

G01N 33/574
C07K 16/30

US Classification:

435007230, 530388800

Abstract:

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

US Patent:

20100190176, Jul 29, 2010

Filed:

Apr 1, 2010

Appl. No.:

12/752827

Inventors:

Peter Steck - Bellaire TX, US
Mark A. Pershouse - Houston TX, US
Samar A. Jasser - Houston TX, US
Alfred W.K. Yung - Houston TX, US
Sean V. Tavtigian - Salt Lake City UT, US

Assignee:

Board of Regents, The University of Texas System - Austin TX
Myriad Genetics, Incorporated - Salt Lake City UT

International Classification:

C12Q 1/68
C07H 21/04
C12P 19/34

US Classification:

435 6, 536 231, 435 915

Abstract:

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

US Patent:

20120315631, Dec 13, 2012

Filed:

Apr 23, 2012

Appl. No.:

13/453324

Inventors:

Peter Steck - Bellaire TX, US
Mark A. Pershouse - Houston TX, US
Samar A. Jasser - Houston TX, US
Alfred W.K. Yung - Houston TX, US
Sean V. Tavtigian - Salt Lake City UT, US

Assignee:

Myriad Genetics, Incorporated - Salt Lake City UT
Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 1/68
G01N 21/64

US Classification:

435 611

Abstract:

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

US Patent:

62622420, Jul 17, 2001

Filed:

Jan 30, 1997

Appl. No.:

8/791115

Inventors:

Peter Steck - Bellaire TX
Mark A. Pershouse - Houston TX
Samar A. Jasser - Houston TX
W. K. Alfred Yung - Houston TX
Sean V. Tavtigian - Salt Lake City UT

Assignee:

Board of Regents, The University of Texas System - Austin TX
Myriad Genetics, Inc. - Salt Lake City UT

International Classification:

C07H 204
C07K 14475
C07K 1447
C12Q 168

US Classification:

536 231

Abstract:

A specific region of chromosome 10 (10q23. 3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23. 3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23. 3, also are disclosed.