Serguei G Popov

US Patent:

20030224403, Dec 4, 2003

Filed:

Feb 27, 2003

Appl. No.:

10/374514

Inventors:

Serguei Popov - Bristow VA, US
Edith Carron - Leonardtown MD, US
Jennifer Cardwell - Manassas VA, US
Taissia Popova - Bristow VA, US
Frank Klotz - Manassas VA, US
Ken Alibek - Bristow VA, US

International Classification:

C12Q001/68

US Classification:

435/006000

Abstract:

Inhibition of LeTx activity is provided as a treatment of anthrax infection. In particular, inhibition of the apoptotic effects of LeTx is provided as a targeted means of specifically treating anthrax infection. Treatments include inhibition of the Fas/FasL signaling pathway, inhibition of the effects of sFasL, inhibition of proteases of the caspase family and protection from loss of mitochondrial transmembrane potential in infected cells. Additionally, treatments targeting inhibition of apoptosis induced by LeTx activity include enhancement of the ERK (MAPK)-signaling pathway by agents including GM-CSF. The method of treating an infectious disease also comprises administering a combination of an antitoxin substance, which protects host cells from microbial toxin, and an antibiotic to an infected person. The anti-toxin substance includes different apoptosis inhibitors. Infection against which the treatment of the invention are effective include any disease leading to apoptosis of host cells such as, but not limited to, anthrax, plague, Ebola, or Marburg.

US Patent:

20040018193, Jan 29, 2004

Filed:

Mar 27, 2003

Appl. No.:

10/400062

Inventors:

Ken Alibek - Bristow VA, US
Charles Bailey - Fayettesville TN, US
Edith Carron - Leonardtown MD, US
Serguei Popov - Bristow VA, US
Aiguo Wu - Arlington VA, US
Taissia Popova - Bristow VA, US
Francis Klotz - Manassas VA, US
Alice Hayford - Silver Srping MD, US
Vladimir Karginov - Ashburn VA, US
Qingzhu Zhai - Centerville VA, US
Ge Liu - Rockville MD, US

International Classification:

A61K039/395

US Classification:

424/144100

Abstract:

A treatment for the effects of biological threat agents, such as smallpox virus or anthrax, to be administered either post-infection or as prophylaxis for infection, comprises administration of IFN-, IFN-, or the cell wall of the bacteria , or or a combination of these components. Additionally, the treatment comprises a combination of antibodies, such as antibodies to heat-inactivated anthrax microbes or to the anthrax Protective Antigen, and antibiotics, such as ciprofloxacin. The treatment also comprises the peptidoglycan, lipoteichoic acid, or muramyl peptide fraction of bacterial cell walls, either alone or in combination with the cytokines, antibodies, and antibiotics provided. These treatments for smallpox and anthrax are administered as an inhalation preparation and therefore avoid the toxic effects of the higher doses of these components. The treatments are also indicated for people at high risk for harmful effects of the smallpox vaccines currently available.

US Patent:

20070231334, Oct 4, 2007

Filed:

Sep 21, 2005

Appl. No.:

11/231600

Inventors:

Ken Alibek - Fairfax VA, US
Taissia Popova - Bristow VA, US
Serguei Popov - Bristow VA, US
Svetlana Hopkins - Arlington VA, US

International Classification:

A61K 39/40
A61K 31/195
A61K 31/473
A61K 36/48
A61K 31/366

US Classification:

424164100, 514566000, 424757000, 514298000, 514460000

Abstract:

The invention provides compositions for treatment anthrax infection. The composition comprises a therapeutically effective amount of at least one metalloprotease inhibitor. The composition may further include an antimicrobial agent. The invention also provides methods for treating anthrax infection in a human or an animal subject. The method comprises administering to the subject a therapeutically effective amount of a composition of the present invention.

US Patent:

20090048293, Feb 19, 2009

Filed:

May 5, 2006

Appl. No.:

11/913518

Inventors:

Serguei Popov - Bristow VA, US
Taissia Popova - Bristow VA, US
Svetlana Nazarenko - Manassas VA, US
Charles Bailey - Cross Junction VA, US
Chris Bradburne - Bristow VA, US
Bryan Millis - Bristow VA, US
Vikas Chandhoke - Fairfax VA, US

International Classification:

A61K 31/47
C12Q 1/02
C12N 9/50
A61P 31/00
C12Q 1/37
G01N 33/53

US Classification:

514312, 435 29, 435 71, 435219, 435 23, 604 502

Abstract:

The present invention provides compositions and methods for detecting, treating, and preventing microbial infection, especially infection caused by (“anthrax”).

US Patent:

20110046039, Feb 24, 2011

Filed:

Mar 6, 2008

Appl. No.:

12/530538

Inventors:

Serguei G. Popov - Bristow VA, US
Taissia Popov - Bristow VA, US
Virginia Espina - Rockville MD, US
Charles Bailey - Cross Junction VA, US
Lance A. Liotta - Bethesda MD, US
Emanuel Petricoin - Gainesville VA, US

Assignee:

George Mason Intellectual Properties Inc. - Fairfax VA

International Classification:

A61K 38/07
A61P 31/04

US Classification:

514 24

Abstract:

The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying non-lethal and lethal exposure to anthrax and similar disease vectors. Embodiments provide materials and methods for using the strains and model systems for differential profiling, such as proteomic profiling, such as differentiation phosphorylation profiling, to target identification and therapeutics discovery and development. Embodiments provide pharmaceutically acceptable compositions, and methods for using them to prevent and/or treat anthrax and similar diseases comprising an agent that decreases the activity of caspase , such as YVAD, and/or an agent that increases the phosphorylation of AKT, such as IB-MECA or Cl-IB-MECA, together with, in particular embodiments, an antibiotic, such as ciprofloxacin. Kits comprising the same are provided as well, among other things.

Address:

10068 Naughton Ct, Bristow, VA 20136

Phone:

7033693192

VIN:

4S4WX82D174410230

Make:

SUBARU

Model:

B9 TRIBECA

Year:

2007