Shalom S Avraham

US Patent:

53407393, Aug 23, 1994

Filed:

Jul 2, 1992

Appl. No.:

7/906871

Inventors:

Richard L. Stevens - Sudbury MA
Shalom Avraham - Brighton MA

Assignee:

Brigham & Women's Hospital - Boston MA

International Classification:

C12N 510
C12N 516
C12N 100
C12N 1563

US Classification:

4352401

Abstract:

A negative transcription regulatory element (a constitutive suppressor) between residues -250 and -190 of the 5' flanking region of the mouse serglycin gene, a positive (hematopoietic cell enhancer) regulatory element located between residues -118 and -81, an equivalent of the TATA- box and a novel eukaryotic promoter that utilizes such equivalent, vectors containing such elements and hosts transformed therewith, are described. These regulatory elements, vectors and hosts are useful in gene transcription of heterologous genes in eukaryotic cells, and especially in hematopoietic cells. In addition, transcriptional factors that bind to these elements are described.

US Patent:

58637443, Jan 26, 1999

Filed:

Oct 3, 1994

Appl. No.:

8/317305

Inventors:

Shalom Avraham - Brookline MA
Hava Avraham - Brookline MA
Jerome E. Groopman - Brookline MA

Assignee:

New England Deaconess Hospital Corporation - Boston MA

International Classification:

G01N 3353

US Classification:

435 721

Abstract:

The invention contemplates the novel neural cell protein marker RR/B, cDNA encoding RR/B, nucleic acid probes for detection of mRNA encoding RR/B, synthetic polypeptides whose sequences correspond to a portion of RR/B and have a molecular weight equal to less than that of RR/B, and methods for detection of RR/B.

US Patent:

60664517, May 23, 2000

Filed:

May 23, 1997

Appl. No.:

8/862508

Inventors:

Shalom Avraham - Brookline MA
Hava Avraham - Brookline MA
Jerome E. Groopman - Brookline MA

Assignee:

Beth Israel Deaconess Medical Center, Inc. - Boston MA

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

The invention contemplates the novel neural cell protein marker RR/B, cDNA encoding RR/B, nucleic acid probes for detection of mRNA encoding RR/B, synthetic polypeptides whose sequences correspond to a portion of RR/B and have a molecular weight equal to less than that of RR/B antibodies specific for RR/B, and methods for detection of RR/B.